Hydroxyzine-d8 DiHCl CAS 1808202-93-8
| CAS No. | 1808202-93-8 |
| Molecular Formula | - |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Hydroxyzine-d8 DiHCl (CAS 1808202-93-8), molecular formula C21H19D8ClN2O2HCl and molecular weight 419.42 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Hydroxyzine-d8 DiHCl (C21H19D8ClN2O2HCl) is characterized by deuterium isotope labeling, a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Hydroxyzine-d8 DiHCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H19D8ClN2O2 2*HCl |
| Molecular Weight | 419.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Hydroxyzine Standards
- Hydroxyzine Pamoate (CAS 10246-75-0)
- Hydroxyzine Impurity 9 (CAS 1031-92-1)
- Hydroxyzine-d8DISCONTINUED (CAS 1189480-47-4)
- Hydroxyzine-d4 2HCl (2-hydroxyethoxy-d4) (CAS 1219805-91-0)
- Hydroxyzine Impurity B Hydrochloride salt (CAS 1263283-80-2)
- Hydroxyzine dihydrochloride (CAS 2192-20-3)
- Hydroxyzine Impurity 5 (CAS 2469273-48-9)
- Hydroxyzine Impurity 2 Dimaleate (Etodroxizine Dimaleate) (CAS 56335-21-8)
Recommended Standards
- 2-(3-Bromo-4-methylphenyl)-2-hydroxyacetic acid (CAS 1261726-45-7)
- ((3S,4R)-4-(4-Chloro-2-fluorophenyl)pyrrolidin-3-yl)methanol hydrochloride (CAS 1217818-45-5)
- 3-Phenylcyclopentanecarboxylic Acid (CAS 91495-75-9)
- 1-(4-Chlorophenyl)-2-((5-(3-chlorophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)ethan-1-one (CAS 874386-23-9)
- (2-Bromooxazol-4-yl)methanol (CAS 1092351-92-2)
- 3,5-Dimethyl-1-(3-methylbenzyl)-1h-pyrazol-4-amine (CAS 955964-94-0)
- 2-Chloro-N-ethylaniline (CAS 13519-74-9)
- N-(Furan-3-ylmethyl)-N-(2-methoxyethyl)-1,3,5-trimethyl-1H-pyrazole-4-sulfonamide (CAS 1448122-98-2)
- Diclofenac sodium Impurity 39 (CAS CATO-C4X-105139)
- Des-Leu26-Tirzepatide (CAS CATO-CPTD788947)
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