Apremilast Impurity 6 CAS 1809170-71-5
| CAS No. | 1809170-71-5 |
| Molecular Formula | C22H26N2O8S |
| Molecular Weight | 478.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Apremilast Impurity 6 (CAS 1809170-71-5) is a certified pharmaceutical impurity reference standard with the molecular formula C22H26N2O8S and a molecular weight of 478.52 g/mol.
Apremilast Impurity 6 (C22H26N2O8S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C22H26N2O8S |
| Molecular Weight | 478.52 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Apremilast Standards
- Apremilast Impurity 7 (CAS 2096492-41-8)
- Apremilast Impurity 115 (CAS 1384814-94-1)
- Apremilast Impurity 32 (CAS CATO-C4X-100932)
- Apremilast Impurity 44 (CAS 2096492-44-1)
- Apremilast Impurity 83 (CAS 2096492-43-0)
- Apremilast impurity 10 (CAS CATO-C4X-100910)
- Apremilast Impurity 69 (CAS CATO-C4X-100969)
- Apremilast-d8 (CAS 1258597-45-3)
Recommended Standards
- N-(Methylsulfonyl)-N-(4-((3-nitroacridin-9-yl)amino)phenyl)butyramide (CAS 61068-06-2)
- N-(4-(4-Acetamidophenyl)thiazol-2-yl)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-oxopyrrolidine-3-carboxamide (CAS 790237-66-0)
- Ticagrelor Impurity 7 (CAS 220347-05-7)
- Methyl 3-nitro-4-{4-[(5Z)-4-oxo-5-[(2E)-3-phenylprop-2-en-1-ylidene]-4,5-dihydro-1,3-thiazol-2-yl]piperazin-1-yl}benzoate (CAS 860651-21-4)
- Chlorpromazine EP Impurity D HCI (CAS 3953-65-9)
- Atrasentan Impurity 84 (CAS 1058552-29-6)
- LCZ-696 Impurity 46 (CAS CATO-C4X-169646)
- 3-Methylisoxazol-5(4H)-one (CAS 1517-96-0)
- 4,6-dimethyl-5-hydroxy-indan-1-one (CAS 381220-71-9)
- (3-(Methylamino)benzofuran-2-yl)(phenyl)methanone (CAS 301538-59-0)
- (E)-7-(but-2-en-1-yl)-8-imino-3-methyl-3,7,8,9-tetrahydro-1H-purine-2,6-dione (CAS 303973-87-7)
- 2,2-Dichlorobutane-1,1,4-triyl triacetate (CAS 141942-59-8)
- 1-Iodo-4,5-dimethyl-2-nitrobenzene (CAS 39763-72-9)
- Peptide Impurity 34 (CAS 21282-09-7)
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