Apremilast Impurity 83 CAS 2096492-43-0
| CAS No. | 2096492-43-0 |
| Molecular Formula | C22H24N2O8S |
| Molecular Weight | 476.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Apremilast Impurity 83 (CAS 2096492-43-0, C22H24N2O8S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Apremilast Impurity 83 (C22H24N2O8S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 476.50 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Apremilast Impurity 83 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H24N2O8S |
| Molecular Weight | 476.50 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Apremilast Standards
- Apremilast Impurity 115 (CAS 1384814-94-1)
- Apremilast Impurity 32 (CAS CATO-C4X-100932)
- Apremilast Impurity 44 (CAS 2096492-44-1)
- Apremilast impurity 10 (CAS CATO-C4X-100910)
- Apremilast Impurity 69 (CAS CATO-C4X-100969)
- Apremilast Impurity 6 (CAS 1809170-71-5)
- Apremilast Impurity 7 (CAS 2096492-41-8)
- Apremilast-d8 (CAS 1258597-45-3)
Recommended Standards
- 4,4'-(((Phenylphosphinediyl)bis(4,1-phenylene))bis(oxy))dianiline (CAS 121566-10-7)
- Canagliflozin Impurity 13 (CAS 2247196-28-5)
- Canagliflozin Impurity 32 (CAS CATO-C4X-112332)
- 5-Benzyl-3-{4-[(4-fluorophenyl)methoxy]-3-methoxyphenyl}-2-methyl-hexahydro-2H-pyrrolo[3,4-d][1,2]oxazole-4,6-dione (CAS 317821-81-1)
- Naltrexone impurity 40 (CAS CATO-C4X-147540)
- Peridine Impurity 17 (CAS 57611-57-1)
- Carbocisteine Impurity 49 (CAS 907565-13-3)
- 5-Morpholinopyrazolo[1,5-a]quinazoline-3-carbonitrile (CAS 124570-61-2)
- 2-((2-Chloro-6-fluorobenzyl)thio)-4,5-diisobutyl-1-propyl-1H-imidazole (CAS 338966-20-4)
- 3,4-Dihydro-7-Methyl-2H-1,4-Benzothiazine (CAS 153953-26-5)
- (S)-(2-Carboxy-2-((methoxycarbonyl)amino)ethyl)triphenylphosphonium chloride (CAS 96854-29-4)
- 3-(Difluoromethoxy)-5-fluorobenzene-1-sulfonyl chloride (CAS 1261776-35-5)
- N-Benzylnortropinone (CAS 28957-72-4)
- Des-Gln19-Tirzepatide (CAS CATO-CPTD788954)
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