Sacubitril impurity 18 CAS 1810778-75-6
| CAS No. | 1810778-75-6 |
| Molecular Formula | C20H25NO3 |
| Molecular Weight | 327.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Sacubitril impurity 18 (CAS 1810778-75-6), a pharmacopoeial impurity reference standard (molecular formula C20H25NO3, MW 327.42 g/mol) used for the identification and quantification of trace impurities in APIs.
Sacubitril impurity 18 (C20H25NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H25NO3 |
| Molecular Weight | 327.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 1 |
Related Sacubitril Standards
- Sacubitril impurity 13 (CAS 2413471-23-3)
- Sacubitril impurity 11 (CAS 182192-86-5)
- Sacubitril Valsartan Sodium Impurity 3 (CAS 1907737-76-1)
- Sacubitril Impurity 38 (CAS CATO-C4X-280938)
- Sacubitril Valsartan Sodium Impurity 2 (CAS 2806120-13-6)
- Sacubitril Impurity 55 (CAS 149818-98-4)
- Sacubitril Impurity 25 (CAS CATO-C4X-280925)
- Sacubitril Impurity 57 (CAS 556828-95-6)
Recommended Standards
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- 2-(Methylthio)quinazolin-4(3H)-one (CAS 54855-81-1)
- 5-(4-Fluorophenyl)pyrrolidin-3-ol hydrochloride (CAS 1423034-84-7)
- tert-Butyl 6-chloro-4-methyl-1H-pyrazolo[4,3-c]pyridine-1-carboxylate (CAS 2769716-32-5)
- 3,3-Dimethylcyclobutane-1-sulfonyl chloride (CAS 1936056-10-8)
- Semaglutide impurity 258 (CAS CATO-C4X-2226258)
Why CATO?
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