Naproxen Impurity N3 CAS 72337-73-6
| CAS No. | 72337-73-6 |
| Molecular Formula | C14H13BrO2 |
| Molecular Weight | 293.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Naproxen Impurity N3 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Naproxen Impurity N3 (CAS 72337-73-6), a pharmacopoeial impurity reference standard (molecular formula C14H13BrO2, MW 293.16 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Naproxen Impurity N3 (C14H13BrO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H13BrO2 |
| Molecular Weight | 293.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Br-containing |
Related Naproxen Standards
- Naproxen Impurity 36 (CAS CATO-C4X-170836)
- Naproxen Impurity 16 (CAS CATO-C4X-170816)
- Naproxen Impurity 18 (CAS 2601735-81-1)
- Naproxen Glycerol Ester Impurity (CAS 38835-17-5)
- Naproxen Impurity 34 (CAS CATO-C4X-170834)
- Naproxen Impurity 35 (CAS CATO-C4X-170835)
- Naproxen Impurity 47 (CAS 99705-42-7)
- Naproxen Impurity 20 (CAS 27655-95-4)
Recommended Standards
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com