Sacubitril impurity 11 CAS 182192-86-5
| CAS No. | 182192-86-5 |
| Molecular Formula | C20H23NO3 |
| Molecular Weight | 325.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 325.40 g/mol gives Sacubitril impurity 11 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Sacubitril impurity 11 (CAS 182192-86-5, C20H23NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Sacubitril impurity 11 (C20H23NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H23NO3 |
| Molecular Weight | 325.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Nitrogen Atoms | 1 |
Related Sacubitril Standards
- Sacubitril Valsartan Sodium Impurity 3 (CAS 1907737-76-1)
- Sacubitril impurity 18 (CAS 1810778-75-6)
- Sacubitril impurity 13 (CAS 2413471-23-3)
- Sacubitril Impurity 38 (CAS CATO-C4X-280938)
- Sacubitril Valsartan Sodium Impurity 2 (CAS 2806120-13-6)
- Sacubitril Impurity 25 (CAS CATO-C4X-280925)
- Sacubitril Impurity 55 (CAS 149818-98-4)
- Sacubitril Impurity 57 (CAS 556828-95-6)
Recommended Standards
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