4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one CAS 182495-80-3
| CAS No. | 182495-80-3 |
| Molecular Formula | C10H14FN3O4 |
| Molecular Weight | 259.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one (C10H14FN3O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one (CAS 182495-80-3), molecular formula C10H14FN3O4 and molecular weight 259.23 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H14FN3O4 |
| Molecular Weight | 259.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
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- 2-(4-Fluorobenzamido)benzoic acid (CAS 18600-61-8)
- 2-[(acetylsulfanyl)methyl]butanedioic acid (CAS 192879-20-2)
- Methyl 2-(hydroxymethyl)-4-methoxybenzo[d]thiazole-6-carboxylate (CAS 2721374-61-2)
- (2-((2,6-Dimethylmorpholino)methyl)phenyl)methanamine (CAS 926244-47-5)
- 25T7-NBOMe HCl (CAS 1539266-55-1)
- 3,4-Dimethylnaphthalen-1-amine (CAS 87031-39-8)
- 1-Aminocyclohexanecarboxylic acid hydrochloride (CAS 39692-17-6)
- (5aS,9aR,10aS,11aR)-4,5,5a,10a,11,11a-Hexahydro-5a-methyl-8-(1-methylethyl)-1H-oxireno[8a,9]phenanthro[1,2-c]furan-3,9-dione (CAS 225787-03-1)
- (2S)-2-[[(4-Methoxyphenyl)methyl]amino]-1-propanol (CAS 570398-18-4)
- (4-Isopropylpyridin-3-yl)boronic acid (CAS 1627723-05-0)
- Semaglutide impurity 204 (CAS CATO-C4X-2226204)
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