Cabazitaxel Impurity N1 CAS 183133-94-0
| CAS No. | 183133-94-0 |
| Molecular Formula | C31H40O10 |
| Molecular Weight | 572.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Cabazitaxel Impurity N1 (CAS 183133-94-0, C31H40O10) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Cabazitaxel Impurity N1 (C31H40O10) contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C31H40O10 |
| Molecular Weight | 572.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
Related Cabazitaxel Standards
- Cabazitaxel Impurity 12 (CAS CATO-C4X-111512)
- Cabazitaxel Impurity 1 (CAS 183133-97-3)
- Cabazitaxel Impurity 3 (CAS 1444818-14-7)
- Cabazitaxel Impurity 6 (CAS CATO-C4X-11156)
- Cabazitaxel Impurity 9 (CAS 1584118-06-8)
- Cabazitaxel Impurity 37 (CAS CATO-C4X-111537)
- Cabazitaxel Impurity 25 (CAS 1638286-64-2)
- Cabazitaxel Impurity N4 (CAS 1262147-55-6)
Recommended Standards
- (3aS,8aS)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine (CAS 300811-56-7)
- 1,1,2,2-Tetrakis(3,4-dimethoxyphenyl)ethene (CAS 59116-22-2)
- (3aR,8aR)-2,2-Dimethyl-4,4,6,8,8-pentaphenyltetrahydro-[1,3]dioxolo[4,5-e][1,3,2]dioxaphosphepine (CAS 147700-62-7)
- 2-(Ethylsulfanyl)-3-methyl-1,4-dihydronaphthalene-1,4-dione (CAS 2593-56-8)
- Ibrutinib Impurity 177 (CAS CATO-C4X-1064177)
- Lefamulinum Impurity 23 (CAS CATO-C4X-304723)
- Agomelatine Impurity 7 (CAS 166526-99-4)
- 1-(Quinazolin-4-yl)azetidin-3-amine (CAS 1340467-59-5)
- 4-Chloro-3-(difluoromethyl)-6-methylpyridine-2-sulfonamide (CAS 1804494-55-0)
- [4-(2-Thienyl)phenyl]acetonitrile (CAS 209592-55-2)
- 2,4-Dichloro-5-(n-(2-(pyridin-2-yl)ethyl)sulfamoyl)benzoic acid (CAS 725710-61-2)
- (1-(2-Fluorobenzyl)-1H-pyrazol-4-yl)methanamine (CAS 1339798-67-2)
- Dipyridamole (CAS 58-32-2)
- Eledoisin Related Peptide (CAS 2990-43-4)
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