Cabazitaxel Impurity 1 CAS 183133-97-3
| CAS No. | 183133-97-3 |
| Molecular Formula | C30H38O10 |
| Molecular Weight | 558.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Cabazitaxel Impurity 1 (CAS 183133-97-3) is a certified pharmaceutical impurity reference standard with the molecular formula C30H38O10 and a molecular weight of 558.62 g/mol.
The molecular framework of Cabazitaxel Impurity 1 (C30H38O10) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C30H38O10 |
| Molecular Weight | 558.62 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
Related Cabazitaxel Standards
- Cabazitaxel Impurity 3 (CAS 1444818-14-7)
- Cabazitaxel Impurity 37 (CAS CATO-C4X-111537)
- Cabazitaxel Impurity N1 (CAS 183133-94-0)
- Cabazitaxel Impurity 12 (CAS CATO-C4X-111512)
- Cabazitaxel Impurity 6 (CAS CATO-C4X-11156)
- Cabazitaxel Impurity 9 (CAS 1584118-06-8)
- Cabazitaxel Impurity N4 (CAS 1262147-55-6)
- Cabazitaxel Impurity N2 (CAS 949459-76-1)
Recommended Standards
- (E)-3-(4-(benzyloxy)-3-hydroxyphenyl)-1-(2,4-bis(benzyloxy)-6-hydroxyphenyl)prop-2-en-1-one (CAS CATO-C3D-262412)
- Pactamycin (CAS 23668-11-3)
- Irinotecan EP Impurity A (CAS 103816-16-6)
- (R)-methyl 5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate (CAS 929095-51-2)
- Finerenone Impurity 125 (CAS CATO-C4X-2880125)
- Upadacitinib Impurity 154 (CAS CATO-C4X-2405154)
- Azilsartan Impurity 167 (CAS CATO-C4X-1096167)
- 2-[(3S,4S)-1-(Aminomethyl)-3,4-dimethylcyclopentyl]acetic acid (CAS 223445-75-8)
- 2-Phenylbicyclo[2.2.1]hept-2-ene (CAS 4237-08-5)
- 7H-Pyrrolo[2,3-d]pyrimidine-5-methanol, 4-chloro-7-[2-deoxy-3,5-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-beta-D-erythro-pentofuranosyl]- (CAS 1200462-11-8)
- 3-Pyrrolidin-2-ylisoxazole hydrochloride (CAS 1332528-62-7)
- (2S,3S)-1-ethyl-2-(2-methoxyphenyl)-6-oxopiperidine-3-carboxylic acid (CAS 1391476-66-6)
- Nilotinib Impurity 13 (CAS CATO-C4X-125613)
- Tirzepatide Impurity 26 X TFA Salt (CAS CATO-C4X-324026)
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