Cabazitaxel Impurity N2 CAS 949459-76-1
| CAS No. | 949459-76-1 |
| Molecular Formula | C24H21NO5 |
| Molecular Weight | 403.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Cabazitaxel Impurity N2 (CAS 949459-76-1, C24H21NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Cabazitaxel Impurity N2 (C24H21NO5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H21NO5 |
| Molecular Weight | 403.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 1 |
Related Cabazitaxel Standards
- Cabazitaxel Impurity N4 (CAS 1262147-55-6)
- Cabazitaxel Impurity 19 (CAS 859498-34-3)
- Cabazitaxel Impurity 22 (Mixture of Diastereomers) (CAS CATO-C4X-111523)
- Cabazitaxel Impurity 28 (CAS 949459-78-3)
- Cabazitaxel Impurity 34 (CAS CATO-C4X-111534)
- Cabazitaxel Impurity 37 (CAS 131023-37-5)
- Cabazitaxel Impurity 37 (CAS CATO-C4X-111537)
- Cabazitaxel Impurity 1 (CAS 183133-97-3)
Recommended Standards
- Fmoc-D-Tyr-OH (CAS 112883-29-1)
- Phthalylsulfathiazole (CAS 85-73-4)
- N-methyl-2-(1-phenyl-3-vinylnaphthalen-2-yl)-4-(trifluoromethyl)aniline (CAS 1383543-50-7)
- Nemonoxacin Impurity 87 (CAS CATO-C4X-312887)
- Oseltamivir Impurity 85 (CAS CATO-C4X-172085)
- Methotrexate Hydrate EP Impurity B (CAS 1217459-90-9)
- Triclopyr impurity B (CAS CATO-CCPD103605)
- 4-Chloro-2-(((4-methoxyphenyl)amino)methyl)phenol (CAS 98591-11-8)
- 2-(2-Bromo-7-fluoro-6-methylbenzofuran-3-yl)acetic acid (CAS 1420793-09-4)
- Ethyl 3-amino-5-(p-tolyl)thiophene-2-carboxylate (CAS 37572-22-8)
- 4-Ethyl-1,2-dimethoxycyclohexa-1,4-diene (CAS 52662-22-3)
- 2,5-Dimethylbenzo[b]thiophene (CAS 16587-48-7)
- 3-(5-(4-Chlorophenyl)furan-2-yl)-N-(2,4-dimethylphenyl)propanamide (CAS 853311-69-0)
- Semaglutide impurity 51 (CAS CATO-C4X-222651)
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