Gefitinib (dihydrochloride) CAS 184475-56-7
| CAS No. | 184475-56-7 |
| Molecular Formula | C22H24ClFN4O3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Gefitinib (dihydrochloride) (CAS 184475-56-7) is a high-purity analytical reference standard with the molecular formula C22H24ClFN4O3HCl and a molecular weight of 483.36 g/mol.
Structurally, Gefitinib (dihydrochloride) (C22H24ClFN4O3HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 483.36 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Gefitinib (dihydrochloride) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H24ClFN4O3 2*HCl |
| Molecular Weight | 483.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Gefitinib Standards
- Gefitinib Impurity 48 (CAS 1006378-06-8)
- Gefitinib-d3 (CAS 1173976-40-3)
- Gefitinib-d8 (CAS 1228664-49-0)
- Gefitinib Impurity 28 (CAS 1379208-77-1)
- Gefitinib Impurity 1 (CAS 1502829-45-9)
- Gefitinib Impurity 19 (CAS 153437-78-6)
- Gefitinib Impurity 58 DiHCl (CAS 1561173-24-7（1*HCl Salt)）)
- Gefitinib Impurity 10 (CAS 1603814-04-5)
Recommended Standards
- rel-(1S,2S,3R,4R)-3-Amino-N-neopentylbicyclo[2.2.1]heptane-2-carboxamide hydrochloride (CAS 2787518-68-5)
- 4-Amino-3-isobutoxy-N,N-dimethylbenzamide (CAS 1406158-74-4)
- 3-Methyl-2-nitrophenylacetic acid (CAS 18710-86-6)
- 1-Iodo-1H,1H,2H,2H-perfluoroheptane (CAS 1682-31-1)
- 1-Chloro-5-(3,4-dimethoxyphenyl)-5-oxopentane (CAS 33245-77-1)
- (S)-2-Aminononanoic acid (CAS 133444-84-5)
- 3-(tert-Butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-amine (CAS 227623-26-9)
- n1,n4-Bis(3-(trifluoromethyl)phenyl)piperazine-1,4-dicarboxamide (CAS 710329-29-6)
- 17alphalpha-(3-Hydroxypropyl)-6beta,7beta,15beta,16beta-dimethylenandrost-4-en-17beta-ol-3-one (CAS 69651-50-9)
- Gastric Inhibitory Polypeptide (1-30) amide (porcine) (CAS 134846-93-8)
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