Selumetinib Impurity 16 CAS CATO-C4X-305316
| CAS No. | CATO-C4X-305316 |
| Molecular Formula | C15H11ClFN3O2 |
| Molecular Weight | 319.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Selumetinib Impurity 16 (CAS CATO-C4X-305316), a pharmacopoeial impurity reference standard (molecular formula C15H11ClFN3O2, MW 319.72 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Selumetinib Impurity 16 (C15H11ClFN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Selumetinib Impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H11ClFN3O2 |
| Molecular Weight | 319.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Selumetinib Standards
- Selumetinib Impurity 9 (CAS CATO-C4X-30539)
- Selumetinib Impurity 1 (CAS CATO-C4X-30531)
- Selumetinib Impurity 21 (CAS CATO-C4X-305321)
- Selumetinib Impurity 8 (CAS CATO-C4X-30538)
- Selumetinib Impurity 6 (CAS CATO-C4X-30536)
- Selumetinib Impurity 7 (CAS CATO-C4X-30537)
- Selumetinib Impurity 20 (CAS CATO-C4X-305320)
- Selumetinib Impurity 12 (CAS CATO-C4X-305312)
Recommended Standards
- Gefitinib Impurity 7 (CAS 184475-71-6)
- 3-(4-Chlorophenyl)sulfanyl-1-methyl-5-(trifluoromethyl)pyridin-2-one (CAS 1924322-42-8)
- 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol (CAS 612501-52-7)
- (2-chloro-7,8-dihydroquinolin-5-yl) trifluoromethanesulfonate (CAS 2752449-77-5)
- Glycyrrhizic Acid Impurity 11 (CAS CATO-C4X-253711)
- Betamethasone EP Impurity E (CAS 981-34-0)
- Pranoprofen Impurity 26 (CAS 86618-09-9)
- N-(2-Ethylphenyl)-2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide (CAS 852369-13-2)
- 6-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE 6-nitro-2H-benzo[b][1,4]oxazin-3(4H)-one 81721-87-1 (CAS 81721-87-1)
- 5-((2-Chlorophenoxy)methyl)furan-2-carboxylic acid (CAS 364609-04-1)
- 2-Amino-5H-purine-6-carboxamide (CAS 882213-43-6)
- (4-Bromo-2,5-difluorophenyl)methanamine hydrochloride (CAS 2059988-69-9)
- Methyl 6-[(E)-2-(dimethylamino)ethenyl]-2-oxo-3-[3-(trifluoromethyl)benzamido]-2H-pyran-5-carboxylate (CAS 341966-20-9)
- Semaglutide Impurity 187 (CAS CATO-C4X-2226187)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com