Bedaquiline Impurity 22 CAS 1849588-75-5
| CAS No. | 1849588-75-5 |
| Molecular Formula | C28H20BrNO2 |
| Molecular Weight | 482.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Bedaquiline Impurity 22 (CAS 1849588-75-5) is a certified pharmaceutical impurity reference standard with the molecular formula C28H20BrNO2 and a molecular weight of 482.37 g/mol.
The molecular framework of Bedaquiline Impurity 22 (C28H20BrNO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H20BrNO2 |
| Molecular Weight | 482.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Bedaquiline Standards
- Bedaquiline Impurity N21 (CAS 1298044-25-3)
- Bedaquiline Impurity 38 (CAS CATO-C4X-116738)
- Bedaquiline Impurity 8 (CAS 2122862-01-3)
- Bedaquiline Impurity 32 (CAS CATO-C4X-116732)
- Bedaquiline Impurity 33 (CAS CATO-C4X-116733)
- Bedaquiline Impurity 34 (CAS CATO-C4X-116734)
- Bedaquiline Impurity 35 (CAS CATO-C4X-116735)
- Bedaquiline Impurity 54 (CAS CATO-C4X-116754)
Recommended Standards
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- 2-Bromo-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl]-N-methyl-D-tryptophan Methyl Ester (CAS 134781-89-8)
- 2'-(4-(2,4-Dichlorophenyl)thiazol-2-yl)-5,5'-dimethyl-2-phenyl-1',2'-dihydro-2H,3'H-[3,4'-bipyrazol]-3'-one (CAS 245039-21-8)
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- tert-Butyl (1-(3-aminophenyl)pyrrolidin-3-yl)carbamate (CAS 889948-29-2)
- N'-(4-(Diethylamino)-2-hydroxybenzylidene)isonicotinohydrazide (CAS 140405-36-3)
- 3,4-Dimethyl-N-[2-(4-methylphenoxy)propyl]aniline (CAS 1040687-59-9)
- Ritalinic acid hydrochloride, threo, racemic (CAS 1382859-13-3)
- 3-Chloro-5-methoxybenzonitrile (CAS 473923-96-5)
- Liraglutide(14-22)TFA Salt (CAS CATO-C4X-199212)
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