Bedaquiline Impurity 33 CAS CATO-C4X-116733
| CAS No. | CATO-C4X-116733 |
| Molecular Formula | C29H24BrNO2 |
| Molecular Weight | 498.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Bedaquiline Impurity 33 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Bedaquiline Impurity 33 (CAS CATO-C4X-116733, C29H24BrNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Bedaquiline Impurity 33 (C29H24BrNO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 18.0, corresponding to approximately 18 ring(s) or double-bond equivalent(s). With a molecular weight of 498.41 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C29H24BrNO2 |
| Molecular Weight | 498.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Bedaquiline Standards
- Bedaquiline Impurity 32 (CAS CATO-C4X-116732)
- Bedaquiline Impurity 34 (CAS CATO-C4X-116734)
- Bedaquiline Impurity 35 (CAS CATO-C4X-116735)
- Bedaquiline Impurity 54 (CAS CATO-C4X-116754)
- Bedaquiline Impurity N21 (CAS 1298044-25-3)
- Bedaquiline Impurity 22 (CAS 1849588-75-5)
- Bedaquiline Impurity 38 (CAS CATO-C4X-116738)
- Bedaquiline Impurity 8 (CAS 2122862-01-3)
Recommended Standards
- N-[5-(3,4-Dimethoxyphenyl)-15,17-dioxa-3,7,8-triazapentacyclo[10.7.0.0^{2,10}.0^{4,8}.0^{14,18}]nonadeca-1(19),2,4,6,9,12,14(18)-heptaen-11-yl]-2,2,2-trifluoroacetamide (CAS 866144-83-4)
- Ethyl 3-(1,3-dioxo-2,3-dihydro-1H-inden-2-ylidene)-4,6-dioxo-5-[3-(trifluoromethyl)phenyl]-octahydropyrrolo[3,4-c]pyrrole-1-carboxylate (CAS 321522-10-5)
- 9-([1,1'-Biphenyl]-4-yl)-11-bromo-9H-dibenzo[a,c]carbazole (CAS 1956379-30-8)
- 1-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-[5-(3-nitrophenyl)-1H-pyrazol-3-yl]piperidine (CAS 1025724-72-4)
- Flurbiprofen Impurity 25 (CAS 91503-88-7)
- Lansoprazole Impurity 11 (CAS 1329838-16-5)
- Mirodenafil Impurity 1 (CAS 2253688-28-5)
- 3-(chloromethyl)-5-(2-chlorophenyl)-1,2-oxazole (CAS 339019-69-1)
- 2-(Trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid (CAS 2567560-43-2)
- (4-Fluoro-6-methylpyridin-3-yl)boronic acid (CAS 2225171-53-7)
- Dimethyl-N,N-diisopropylphosphoramidite (CAS 122194-07-4)
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- Liraglutide(10-22)TFA Salt (CAS CATO-C4X-199211)
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