Sorafenib EP Impurity G CAS 18585-06-3
| CAS No. | 18585-06-3 |
| Molecular Formula | C10H9ClF3NO2 |
| Molecular Weight | 267.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Sorafenib EP Impurity G (C10H9ClF3NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Sorafenib EP Impurity G (CAS 18585-06-3) is a certified pharmaceutical impurity reference standard with the molecular formula C10H9ClF3NO2 and a molecular weight of 267.63 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H9ClF3NO2 |
| Molecular Weight | 267.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Sorafenib Standards
- Sorafenib EP Impurity B (CAS 2004659-84-9)
- Sorafenib Impurity 56 (CAS 864272-34-4)
- Sorafenib Impurity 60 (CAS 284462-86-8)
- Sorafenib Impurity 11 (CAS 1129683-88-0)
- Sorafenib impurity 65 (CAS CATO-C4X-112465)
- Sorafenib Impurity 29 (CAS CATO-C4X-112429)
- Sorafenib Impurity 27 (CAS 757251-59-5)
- Sorafenib Impurity 61 (CAS 284462-78-8)
Recommended Standards
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- Ethyl 4-chloro-2-methyl-6-(trifluoromethyl)nicotinate (CAS 2451906-26-4)
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- cis-9,trans-12-Tetradecadienyl acetate (CAS 31654-77-0)
- 6-Methoxy-1-methyl-1H-indol-5-ol (CAS 1028694-86-1)
- 2-(4-(Aminomethyl)piperidin-1-yl)-1-(thiophen-2-yl)ethanone hydrochloride (CAS 1353954-82-1)
- Peptide Impurity 26 (CAS 1350456-66-4)
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