Nilotinib EP Impurity B CAS 18595-18-1
| CAS No. | 18595-18-1 |
| Molecular Formula | C9H11NO2 |
| Molecular Weight | 165.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 165.19 g/mol gives Nilotinib EP Impurity B distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Nilotinib EP Impurity B (CAS 18595-18-1, C9H11NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nilotinib EP Impurity B (C9H11NO2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Nilotinib EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H11NO2 |
| Molecular Weight | 165.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Nitrogen Atoms | 1 |
Related Nilotinib Standards
- Nilotinib Impurity 17 (CAS 18595-17-0)
- Nilotinib 2-Pyridinyl Impurity (CAS 66521-65-1)
- (Z)-Nilotinib Impurity 37 (CAS 75415-01-9)
- Nilotinib Hydrochloride Monohydrate EP Impurity C (CAS 2458-12-0)
- Nilotinib Impurity 25 (CAS 41574-91-8)
- Nilotinib Impurity 50 (CAS CATO-C4X-125650)
- Nilotinib Impurity 51 (CAS CATO-C4X-125651)
- Nilotinib Impurity 40 (CAS 859026-97-4)
Recommended Standards
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- 2-((3aS,8aR)-3a,8a-dihydro-8H-indeno[1,2-d]oxazol-2-yl)acetonitrile (CAS 175166-50-4)
- Semaglutide Impurity 160 (x TFA Salt) (CAS CATO-C4X-2226160)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com