Ambroxol EP Impurity B CAS 18683-95-9
| CAS No. | 18683-95-9 |
| Molecular Formula | C14H18Br2N2O |
| Molecular Weight | 390.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ambroxol EP Impurity B (CAS 18683-95-9) is a certified pharmaceutical impurity reference standard with the molecular formula C14H18Br2N2O and a molecular weight of 390.11 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Ambroxol EP Impurity B is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 390.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Ambroxol EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H18Br2N2O |
| Molecular Weight | 390.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Ambroxol Standards
- Ambroxol Impurity 17 (CAS CATO-C4X-108517)
- Ambroxol Hydrochloride EP Impurity B (CAS CATO-C4X-108546)
- Ambroxol impurity 99 (CAS CATO-C4X-108599)
- Ambroxol impurity 64 (CAS CATO-C4X-108564)
- Ambroxol impurity 106 (CAS CATO-C4X-1085106)
- Ambroxol Impurity 104 (CAS CATO-C4X-1085104)
- Ambroxol impurity 113 (CAS 131417-90-8)
- Ambroxol Impurity 48 (CAS 2646700-91-4)
Recommended Standards
- Bromhexine Impurity 46 (CAS 3472-84-2)
- Bromhexine Impurity 20 (CAS CATO-C4X-106020)
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- Oxacillin Impurity N1 (CAS 37699-31-3)
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- 2-Chloro-3-iodoprop-1-ene (CAS 39557-31-8)
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- 2-(Isobutylsulfonyl)ethanamine (CAS 1092280-20-0)
- Liraglutide(13-31)TFA Salt (CAS CATO-C4X-19929)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com