Ambroxol impurity 64 CAS CATO-C4X-108564
| CAS No. | CATO-C4X-108564 |
| Molecular Formula | C13H19BBr2N2O |
| Molecular Weight | 389.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ambroxol impurity 64 (C13H19BBr2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Ambroxol impurity 64 (CAS CATO-C4X-108564) is a certified pharmaceutical impurity reference standard with the molecular formula C13H19BBr2N2O and a molecular weight of 389.92 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H19BBr2N2O |
| Molecular Weight | 389.92 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Ambroxol Standards
- Ambroxol Impurity 17 (CAS CATO-C4X-108517)
- Ambroxol EP Impurity B (CAS 18683-95-9)
- Ambroxol Hydrochloride EP Impurity B (CAS CATO-C4X-108546)
- Ambroxol impurity 99 (CAS CATO-C4X-108599)
- Ambroxol Impurity 104 (CAS CATO-C4X-1085104)
- Ambroxol impurity 113 (CAS 131417-90-8)
- Ambroxol impurity 106 (CAS CATO-C4X-1085106)
- Ambroxol Impurity 39 (CAS 1797894-71-3)
Recommended Standards
- N-(5-(4-Chlorophenyl)-1,3,4-thiadiazol-2-yl)-2-(phenylthio)butanamide (CAS 394237-13-9)
- Tungsten(V) dichloride triethoxide, 10% w/v in ethanol (CAS 45000-93-9)
- N-(3-chlorophenyl)-2-((5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)thio)acetamide (CAS 332162-08-0)
- 4-Bromo-3-iodo-6-(trifluoromethyl)-1H-indole (CAS 1360951-88-7)
- Vildagliptin Impurity 42 (CAS CATO-C4X-110042)
- Ibrutinib Impurity 92 (CAS CATO-C4X-106492)
- Almotriptan Impurity 15 (CAS CATO-C4X-153815)
- (6-(2-Methoxyethoxy)pyridazin-3-yl)methanamine dihydrochloride (CAS 1909312-48-6)
- 2-(Methylsulfonyl)-2,6-diazaspiro[3.4]octane (CAS 1784624-24-3)
- 4-((4-Iodophenoxy)methyl)benzonitrile (CAS 879146-21-1)
- 4-(Difluoromethyl)-2-methyl-5-nitropyridine (CAS 1803691-99-7)
- (S)-1-(6-Fluorobenzo[d]thiazol-2-yl)ethanamine (CAS 221654-69-9)
- (R)-AntPhos (CAS 1456816-37-7)
- (D-Ala2)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt (CAS 444073-04-5)
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