Formoterol impurity 127 CAS 188690-82-6
| CAS No. | 188690-82-6 |
| Molecular Formula | C15H14BrNO4 |
| Molecular Weight | 352.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Formoterol impurity 127 (CAS 188690-82-6, C15H14BrNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C15H14BrNO4, Formoterol impurity 127 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 352.18 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Formoterol impurity 127 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H14BrNO4 |
| Molecular Weight | 352.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Formoterol Standards
- Formoterol impurity 126 (CAS CATO-C4X-1525126)
- Formoterol Impurity 54 (CAS 193761-53-4)
- Formoterol-d6(Mixture of Diastereomers) (CAS 1020719-45-2)
- Formoterol Impurity 28 (CAS 201677-59-0)
- Formoterol Impurity 59 (CAS 306966-56-3)
- Formoterol impurity 142 (CAS CATO-C4X-1525142)
- Formoterol Impurity 23 (CAS 43229-01-2)
- Formoterol Impurity 69 (CAS 100865-09-6)
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