Verapamil Impurity 8（Verapamil EP Impurity H） CAS 190850-49-8
| CAS No. | 190850-49-8 |
| Molecular Formula | C26H36N2O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Verapamil Impurity 8（Verapamil EP Impurity H）.
CATO supplies Verapamil Impurity 8（Verapamil EP Impurity H） (CAS 190850-49-8), a pharmacopoeial impurity reference standard (molecular formula C26H36N2O4HCl, MW 477.04 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Verapamil Impurity 8（Verapamil EP Impurity H） (C26H36N2O4HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Verapamil Impurity 8（Verapamil EP Impurity H） under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C26H36N2O4 HCl |
| Molecular Weight | 477.04 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2011 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Verapamil Standards
- Verapamil Impurity N1 (CAS 102201-30-9)
- Verapamil Impurity 38 (CAS 114847-42-6)
- Verapamil D6 HCl (CAS 1185032-80-7)
- Verapamil-d7 Hydrochloride (CAS 1188265-55-5)
- Verapamil EP Impurity G (CAS 120-14-9)
- Verapamil EP Impurity J-D7 HCl (CAS 1216413-74-9)
- Verapamil EP Impurity B HCl (CAS 13078-76-7)
- (S)-(-)-Verapamil-d6 Hydrochloride (CAS 1329611-24-6)
Recommended Standards
- Decitabine Impurity 17 (CAS 69304-65-0)
- Posaconazole Impurity 87 (CAS CATO-C4X-120887)
- Agomelatine Impurity 10 (CAS 20176-04-9)
- Tert-butyl 3-(trifluoromethoxy)piperidine-1-carboxylate (CAS 1206524-11-9)
- 2-Cyano-N-(2-cyanoethyl)-N-ethylacetamide (CAS 1247129-57-2)
- 4-Chloro-5-methyl-2-(3-(trifluoromethyl)phenyl)pyridazin-3(2H)-one (CAS 68143-24-8)
- 1,2-Dicarbadodecaborane(12) (CAS 16872-09-6)
- 2-Chloro-6-(difluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1321518-08-4)
- 6-Bromo-2-(trifluoromethyl)oxazolo[4,5-b]pyridine (CAS 1260656-87-8)
- D-Pro37-Tirzepatide (CAS CATO-CPTD788902)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com