Verapamil EP Impurity G CAS 120-14-9
| CAS No. | 120-14-9 |
| Molecular Formula | C9H10O3 |
| Molecular Weight | 166.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Verapamil EP Impurity G.
As a process- or degradation-related impurity, Verapamil EP Impurity G (CAS 120-14-9, C9H10O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Verapamil EP Impurity G is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 166.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Verapamil EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H10O3 |
| Molecular Weight | 166.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Verapamil Standards
- Verapamil Hydrochloride EP Impurity E (CAS 93-03-8)
- Verapamil Impurity N2 (CAS 3017-96-7)
- Verapamil Impurity 24 (CAS 18086-24-3)
- Verapamil Impurity 25 (CAS 3893-01-4)
- Verapamil Impurity 27 (CAS 7306-46-9)
- Verapamil EP Impurity B (CAS 3490-06-0)
- Verapamil EP Impurity L (CAS 14046-55-0)
- Verapamil EP Impurity C (CAS 3490-05-9)
Recommended Standards
- Carbidopa EP Impurity G (CAS 2503-44-8)
- Esmolol Impurity 15 (CAS 501-97-3)
- Ipratropium Bromide EP Impurity C (CAS 552-63-6)
- Methyl Salicylate EP Impurity D (CAS 121-98-2)
- Erlotinib impurity 126 (CAS 183320-00-5)
- Perampanel Impurity 56 (CAS CATO-C4X-243056)
- SAR107375E Impurity 4 (CAS CATO-C4X-22994)
- 5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-1-propyl-1H-pyrazole (CAS 1487355-92-9)
- N-Isopropylindoline-2-carboxamide (CAS 1489394-08-2)
- N-(2-(2-Ethoxyphenoxy)ethyl)-4-phenylbutan-1-amine hydrochloride (CAS 264185-75-3)
- 2-(Hydroxymethyl)benzo[d]oxazole-6-acrylic acid (CAS 1803424-95-4)
- 5-Chloro-N-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide (CAS 899350-98-2)
- 3-{1h,4h,5h,6h-cyclopenta[c]pyrazol-3-yl}aniline (CAS 1118788-10-5)
- Exenatide (CAS 141758-74-9)
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