Verapamil EP Impurity B HCl CAS 13078-76-7
| CAS No. | 13078-76-7 |
| Molecular Formula | C11H17NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Verapamil EP Impurity B HCl (CAS 13078-76-7, C11H17NO2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C11H17NO2HCl, Verapamil EP Impurity B HCl contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 231.72 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H17NO2 HCl |
| Molecular Weight | 231.72 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1960 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Verapamil Standards
- Verapamil Impurity N1 (CAS 102201-30-9)
- Verapamil Impurity 38 (CAS 114847-42-6)
- Verapamil D6 HCl (CAS 1185032-80-7)
- Verapamil-d7 Hydrochloride (CAS 1188265-55-5)
- Verapamil EP Impurity G (CAS 120-14-9)
- Verapamil EP Impurity J-D7 HCl (CAS 1216413-74-9)
- (S)-(-)-Verapamil-d6 Hydrochloride (CAS 1329611-24-6)
- Verapamil EP Impurity L (CAS 14046-55-0)
Recommended Standards
- Empagliflozin Impurity 291 (CAS CATO-C4X-1065291)
- Daptomycin Impurity 35 (CAS CATO-C4X-137835)
- Nicorandil impurity 62 (CAS CATO-C4X-190762)
- 3-(piperidin-1-yl)cyclopentan-1-amine dihydrochloride (CAS 1803610-53-8)
- 2-Chloro-1-(2-thioxoimidazolidin-1-yl)ethanone (CAS 64202-34-2)
- 2,5,6-Trimethyl-1-(3-methylbenzyl)-1H-benzo[d]imidazol-4-amine (CAS 338954-75-9)
- 5-iodoindole (CAS 16066-91-4)
- 3-Chloro-N-(5-cyano-2-((2,6-dichlorophenyl)thio)phenyl)benzamide (CAS 303147-54-8)
- 4-(trans-4-Ethylcyclohexyl)phenol (CAS 89100-78-7)
- [α-Glu](Side Chain)-Semaglutide (CAS CATO-C4X-2226159)
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