Trimethoprim EP Impurity H CAS 1916-07-0
| CAS No. | 1916-07-0 |
| Molecular Formula | C11H14O5 |
| Molecular Weight | 226.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Trimethoprim EP Impurity H (C11H14O5) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Trimethoprim EP Impurity H (CAS 1916-07-0) is a certified pharmaceutical impurity reference standard with the molecular formula C11H14O5 and a molecular weight of 226.23 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Trimethoprim EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H14O5 |
| Molecular Weight | 226.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Trimethoprim Standards
- Trimethoprim Impurity 3 (CAS 14779-44-3)
- Trimethoprim EP Impurity J-D9 (CAS 84759-05-7)
- Trimethoprim Impurity 14 (CAS 154389-62-5)
- Trimethoprim Impurity 2 (CAS 51210-04-9)
- Trimethoprim Impurity 6 (CAS 7520-69-6)
- Trimethoprim Impurity 2 (CAS 72920-13-9)
- Trimethoprim (CAS 738-70-5)
- Trimethoprim EP Impurity D (CAS 92440-76-1)
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