Trimethoprim EP Impurity J-D9 CAS 84759-05-7
| CAS No. | 84759-05-7 |
| Molecular Formula | - |
| Molecular Weight | 221.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 221.25 g/mol gives Trimethoprim EP Impurity J-D9 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Trimethoprim EP Impurity J-D9 (CAS 84759-05-7, C10H3D9O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Trimethoprim EP Impurity J-D9 (C10H3D9O5) contains deuterium isotope labeling, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 9.5, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 221.25 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Trimethoprim EP Impurity J-D9 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H3D9O5 |
| Molecular Weight | 221.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
Related Trimethoprim Standards
- Trimethoprim Impurity 3 (CAS 14779-44-3)
- Trimethoprim EP Impurity H (CAS 1916-07-0)
- Trimethoprim Impurity 14 (CAS 154389-62-5)
- Trimethoprim Impurity 2 (CAS 51210-04-9)
- Trimethoprim Impurity 6 (CAS 7520-69-6)
- Trimethoprim Impurity 2 (CAS 72920-13-9)
- Trimethoprim (CAS 738-70-5)
- Trimethoprim EP Impurity D (CAS 92440-76-1)
Recommended Standards
- 3,3-Diphenyloxirane-2-carbonitrile (CAS 21432-18-8)
- 3,5-Diphenylisoxazole (CAS 2039-49-8)
- 3,3-Dimethoxy-1-(pyridin-3-yl)cyclobutane-1-carbaldehyde (CAS 2609864-87-9)
- 3-[(1-phenylethyl)carbamoyl]propanoic acid (CAS 60756-87-8)
- Morinidazole Impurity 27 (CAS CATO-C4X-219627)
- Bedaquiline Impurity 53 (CAS 654653-95-9)
- Cycloserine Impurity 15 (CAS CATO-C4X-226415)
- Ticagrelor impurity 99 (CAS CATO-C4X-109399)
- 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3,6-difluorobenzoic acid (CAS 2243507-97-1)
- 3-Bromo-5-fluoropicolinic acid (CAS 1189513-55-0)
- 3-(4-Oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(thiophen-2-ylmethyl)propanamide (CAS 440331-67-9)
- 4-(2-Chloroethyl)-1H-imidazole (CAS 13518-55-3)
- tert-Butyl (2S,5S)-5-allylpyrrolidine-2-carboxylate (CAS 549521-70-2)
- Exenatide Acetate (CAS 141732-76-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com