Trimethoprim EP Impurity D CAS 92440-76-1
| CAS No. | 92440-76-1 |
| Molecular Formula | C14H17N3O4 |
| Molecular Weight | 291.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Trimethoprim EP Impurity D (CAS 92440-76-1, C14H17N3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Trimethoprim EP Impurity D (C14H17N3O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Trimethoprim EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H17N3O4 |
| Molecular Weight | 291.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Nitrogen Atoms | 3 |
Related Trimethoprim Standards
- Trimethoprim EP Impurity E (CAS 60729-91-1)
- Trimethoprim (CAS 738-70-5)
- Trimethoprim Impurity 1 (CAS 93885-69-9)
- Trimethoprim-13C3 (CAS 1189970-95-3)
- Trimethoprim-d3 (CAS 1189923-38-3)
- Trimethoprim-d9 (CAS 1189460-62-5)
- Trimethoprim EP Impurity B (CAS 30806-86-1)
- Trimethoprim EP Impurity A (CAS 213745-86-9)
Recommended Standards
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- BnO-PEG4-Boc (CAS 1807503-89-4)
- 6-(Allylthio)-1,2,4-triazine-3,5(2H,4H)-dione (CAS 10237-48-6)
- 302798-54-5 (Leu31,Pro34)-Neuropeptide Y (13-36) (human, rat) MFCD00672463 (CAS 302798-54-5)
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