2-Chloro-5-(2,6-difluorophenyl)pyrazine CAS 1935361-09-3
| CAS No. | 1935361-09-3 |
| Molecular Formula | C10H5ClF2N2 |
| Molecular Weight | 226.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-5-(2,6-difluorophenyl)pyrazine.
2-Chloro-5-(2,6-difluorophenyl)pyrazine (CAS 1935361-09-3), molecular formula C10H5ClF2N2 and molecular weight 226.61 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution, 2-Chloro-5-(2,6-difluorophenyl)pyrazine is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 226.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H5ClF2N2 |
| Molecular Weight | 226.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-5-hydroxy-2-methylbenzofuran-3-carboxylic acid (CAS 114829-18-4)
- 3-Chloro-6-(2,6-difluorophenyl)pyridazine (CAS 1154600-74-4)
- 4-Chloro-2-(3,4-difluorophenyl)pyrimidine (CAS 1156585-24-8)
- (S)-6-Chloro-4-oxochroman-2-carboxylic acid (CAS 1190606-53-1)
- 6-Chloro-4-hydroxy-7-methoxy-2H-chromen-2-one (CAS 1366396-34-0)
- (R)-6-Chloro-4-oxochromane-2-carboxylic acid (CAS 1372625-50-7)
- 3-(7-Chloro-2H-1,3-benzodioxol-5-yl)prop-2-enoic acid (CAS 1633931-69-7)
- Methyl 5-chloro-3-hydroxybenzofuran-2-carboxylate (CAS 172088-81-2)
Recommended Standards
- 2-Chloro-5-(2,3-difluorophenyl)pyrimidine (CAS 193400-11-2)
- 2-Chloro-5-(2,3-difluorophenyl)pyrazine (CAS 1935936-81-4)
- 3-Chloro-7,8-dihydroxy-4-methyl-2H-chromen-2-one (CAS 19149-43-0)
- 2-Chloro-4-(2,5-difluorophenyl)pyrimidine (CAS 894854-16-1)
- 3-Bromo-5-(1H-imidazol-1-yl)pyridine (CAS 263868-66-2)
- N-(methylsulfonyl)-N-(3-(trifluoromethyl)phenyl)glycine (CAS 392313-41-6)
- 4-[(3-aminopropyl)amino]butanoic acid dihydrochloride (CAS 53185-44-7)
- 3-(2,5-Dimethoxyphenyl)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)acrylamide (CAS 1921640-08-5)
- 2-Pyrrolidinecarboxamide, N-[3-(1H-imidazol-1-yl)propyl]-, dihydrochloride, (2S)- (CAS 1590382-03-8)
- 1-(Aminomethyl)-5,6,7,8-tetrahydronaphthalen-2-ol hydrochloride (CAS 1354952-20-7)
- Ethyl 2-(2-methyl-4-piperidyl)acetate (CAS 1283627-33-7)
- 2,6-Dichlorotoluene-3,4,5-d3 (CAS 358731-95-0)
- 5-Fluoro-2-mercaptobenzoic acid (CAS 120121-07-5)
- D-Pro31-Tirzepatide (CAS CATO-CPTD788905)
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