2-Chloro-5-(2,3-difluorophenyl)pyrazine CAS 1935936-81-4
| CAS No. | 1935936-81-4 |
| Molecular Formula | C10H5ClF2N2 |
| Molecular Weight | 226.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-5-(2,3-difluorophenyl)pyrazine (C10H5ClF2N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2-Chloro-5-(2,3-difluorophenyl)pyrazine (CAS 1935936-81-4), molecular formula C10H5ClF2N2 and molecular weight 226.61 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-Chloro-5-(2,3-difluorophenyl)pyrazine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H5ClF2N2 |
| Molecular Weight | 226.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-5-hydroxy-2-methylbenzofuran-3-carboxylic acid (CAS 114829-18-4)
- 3-Chloro-6-(2,6-difluorophenyl)pyridazine (CAS 1154600-74-4)
- 4-Chloro-2-(3,4-difluorophenyl)pyrimidine (CAS 1156585-24-8)
- (S)-6-Chloro-4-oxochroman-2-carboxylic acid (CAS 1190606-53-1)
- 6-Chloro-4-hydroxy-7-methoxy-2H-chromen-2-one (CAS 1366396-34-0)
- (R)-6-Chloro-4-oxochromane-2-carboxylic acid (CAS 1372625-50-7)
- 3-(7-Chloro-2H-1,3-benzodioxol-5-yl)prop-2-enoic acid (CAS 1633931-69-7)
- Methyl 5-chloro-3-hydroxybenzofuran-2-carboxylate (CAS 172088-81-2)
Recommended Standards
- 2-Chloro-5-(2,6-difluorophenyl)pyrazine (CAS 1935361-09-3)
- 2-Chloro-4-(2,5-difluorophenyl)pyrimidine (CAS 894854-16-1)
- 2-Chloro-5-(2,3-difluorophenyl)pyrimidine (CAS 193400-11-2)
- 2-Chloro-4-(3,5-difluorophenyl)pyrimidine (CAS 954218-58-7)
- 2-Aminoimidazole (CAS 7720-39-0)
- 2-((4-Phenyl-5-((3-(trifluoromethyl)phenoxy)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 383145-84-4)
- [4-(4-Fluoro-phenyl)-piperazin-1-yl]-naphthalen-2-yl-acetic acid (CAS 885276-78-8)
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Why CATO?
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