Osimertinib Impurity 94 CAS 1942853-18-0
| CAS No. | 1942853-18-0 |
| Molecular Formula | C24H23N5O3 |
| Molecular Weight | 429.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Osimertinib Impurity 94 (C24H23N5O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Osimertinib Impurity 94 (CAS 1942853-18-0) is a certified pharmaceutical impurity reference standard with the molecular formula C24H23N5O3 and a molecular weight of 429.47 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Osimertinib Impurity 94 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H23N5O3 |
| Molecular Weight | 429.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 5 |
Related Osimertinib Standards
- Osimertinib Impurity 49 (CAS CATO-C4X-204549)
- Osimertinib Impurity 67 (CAS CATO-C4X-204567)
- Osimertinib Impurity 72 (CAS CATO-C4X-204572)
- Osimertinib Impurity 83 (CAS CATO-C4X-204583)
- Osimertinib Impurity 3 (AZD9291 Impurity 3) (CAS CATO-C4X-20453)
- Osimertinib Impurity 62 (CAS CATO-C4X-204562)
- Osimertinib Impurity N3 (CAS 1820891-36-8)
- Osimertinib Impurity 12 (CAS 2213409-62-0)
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