Diclofenac Impurity 19 CAS 1205-40-9
| CAS No. | 1205-40-9 |
| Molecular Formula | C12H10ClN |
| Molecular Weight | 203.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Diclofenac Impurity 19 (CAS 1205-40-9, C12H10ClN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Diclofenac Impurity 19 (C12H10ClN) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 203.67 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C12H10ClN |
| Molecular Weight | 203.67 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac impurity 7 (CAS 2563-99-7)
- Diclofenac Impurity N1 (CAS 131023-43-3)
- Diclofenac Impurity 40 (CAS CATO-C4X-105140)
- Diclofenac sodium Impurity 6 (CAS 70172-33-7)
- Diclofenac impurity 4 (CAS 1928-49-0)
- Diclofenac Impurity 21 (CAS 105836-68-8)
- Diclofenac Sodium Impurity 33 (CAS 58373-59-4)
- Diclofenac sodium Impurity 38 (CAS 15307-93-4)
Recommended Standards
- 4-Chloro-N-phenylaniline (CAS 1205-71-6)
- Chlorphenamine Impurity 20 (CAS 4350-41-8)
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- 4'-Chloro-Biphenyl-2-yl Amine (CAS 1204-44-0)
- Docetaxel EP Impurity A (CAS 1887057-05-7)
- Drotaverin Impurity 53 (CAS CATO-C4X-243553)
- Tizanidine Impurity 45 (CAS CATO-C4X-144545)
- tert-Butyl(2S-cis)-4-(benzyloxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate (CAS 134883-25-3)
- 2-(Difluoromethyl)-6-iodo-5-methylpyridine-3-carboxaldehyde (CAS 1806952-20-4)
- 6-Chloro-1,8-naphthyridin-2(1H)-one (CAS 127446-42-8)
- 2,2-dimethylheptanedinitrile (CAS 500310-59-8)
- 2-amino-4-methyl-1-(thiophen-2-yl)pentan-1-ol (CAS 1181447-86-8)
- Methyl 3-iodo-4-(methylselanyl)benzoate (CAS 874764-42-8)
- Semaglutide impurity 258 (CAS CATO-C4X-2226258)
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