Nintedanib Impurity 137 CAS CATO-C4X-1814137
| CAS No. | CATO-C4X-1814137 |
| Molecular Formula | C10H12Cl2O3 |
| Molecular Weight | 251.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Nintedanib Impurity 137 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Nintedanib Impurity 137 (CAS CATO-C4X-1814137, C10H12Cl2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nintedanib Impurity 137 (C10H12Cl2O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H12Cl2O3 |
| Molecular Weight | 251.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity 135 (CAS CATO-C4X-1814135)
- Nintedanib Impurity 138 (CAS CATO-C4X-1814138)
- Nintedanib Impurity 139 (CAS CATO-C4X-1814139)
- Nintedanib Impurity 141 (CAS CATO-C4X-1814141)
- Nintedanib Impurity 142 (CAS CATO-C4X-1814142)
- Nintedanib Impurity 31 (CAS 2514952-69-1)
- Nintedanib Impurity 11 (CAS CATO-C4X-181411)
- Nintedanib Impurity 25 (CAS 262368-25-2)
Recommended Standards
- 1,2-Bis(4-chlorophenyl)diazene (CAS 1602-00-2)
- 89976-15-8 7-iodo-1H-indole DTXSID00453092 (CAS 89976-15-8)
- Phenacetin Impurity 16 (CAS 30926-04-6)
- Phenacetin Impurity N1 (CAS 21650-51-1)
- Amlodipine Impurity 107 (CAS CATO-C4X-1095107)
- Pemetrexed Impurity 10 (CAS 151864-81-2)
- Tramadol Impurity 21 (CAS CATO-C4X-149821)
- 1-(2-Methoxyethyl)guanidine (CAS 108712-07-8)
- 3,5-Dichloro-alpha-(trifluoromethyl)benzyl Alcohol (CAS 1187989-89-4)
- (4-Aminopiperidin-1-yl)(benzo[d][1,3]dioxol-5-yl)methanone hydrochloride (CAS 1353980-73-0)
- (R)-3-(4-Chlorophenyl)-2-methylpropanoic acid (CAS 199679-74-8)
- Ethyl 2-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)acetate (CAS 1208081-49-5)
- Cilofungin - API Standards (CAS 79404-91-4)
- Liraglutide (CAS 204656-20-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com