Butylphthalide Impurity 9 CAS 19666-03-6
| CAS No. | 19666-03-6 |
| Molecular Formula | C11H12O3 |
| Molecular Weight | 192.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Butylphthalide Impurity 9 (C11H12O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Butylphthalide Impurity 9 (CAS 19666-03-6) is a certified pharmaceutical impurity reference standard with the molecular formula C11H12O3 and a molecular weight of 192.21 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12O3 |
| Molecular Weight | 192.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
Related Butylphthalide Standards
- Butylphthalide Impurity 32 (CAS 60510-95-4)
- Butylphthalide Impurity 46 (CAS 26311-42-2)
- Butylphthalide Impurity 80 (CAS CATO-C4X-181380)
- Butylphthalide Impurity N2 (CAS 20320-37-0)
- 3-Butylphthalide-d3 (CAS 6066-49-5（Unlabelled）)
- Butylphthalide Impurity 41 (CAS 3413-15-8)
- Butylphthalide Impurity 23 (CAS 199736-94-2)
- Butylphthalide Impurity 35 (CAS 16692-58-3)
Recommended Standards
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- Posaconazole Impurity 66 (CAS 165115-83-3)
- Octyl cyanoacetate (CAS 15666-97-4)
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- Clemastine Fumarate EP Impurity A (CAS 61826-32-2)
- 4-((Methylthio)methyl)piperidin-4-ol (CAS 1500735-47-6)
- 2-Chloro-5-fluorobenzoic Acid (CAS 2252-50-8)
- N-(1-(3,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-4-methylbenzenesulfonamide (CAS 339009-18-6)
- Semaglutide impurity 42 (CAS CATO-C4X-222642)
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