Propofol Impurity 22 CAS 1988-10-9
| CAS No. | 1988-10-9 |
| Molecular Formula | C12H18O2 |
| Molecular Weight | 194.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Propofol Impurity 22.
As a process- or degradation-related impurity, Propofol Impurity 22 (CAS 1988-10-9, C12H18O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Propofol Impurity 22 (C12H18O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Propofol Impurity 22 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H18O2 |
| Molecular Weight | 194.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Propofol Standards
- Propofol Impurity 19 (CAS 20748-66-7)
- Propofol-d17 (CAS 1261393-54-7)
- Propofol Impurity 23 (CAS CATO-C4X-147323)
- Propofol EP Impurity J(Propofol Related Compound B) (CAS 1988-11-0)
- Propofol EP Impurity L (CAS 201166-22-5)
- Propofol Impurity 38 (CAS CATO-C4X-147338)
- Propofol Impurity 37 (CAS 494-72-4)
- Propofol Impurity 25 (CAS 92035-95-5)
Recommended Standards
- Itopride Impurity 3 (CAS 20059-73-8)
- Irbesartan Impurity 28 (CAS 194984-24-2)
- Metoprolol Impurity 22 (CAS 123195-72-2)
- Irbesartan Impurity 43 (CAS CATO-C4X-166643)
- Perindopril Impurity 106 (CAS CATO-C4X-1252106)
- Regadenoson Impurity 22 (CAS 2004-07-1)
- Troxipide Impurity 12 (CAS CATO-C4X-214812)
- Risperidone EP Impurity H (CAS 158697-67-7)
- 3-[(2-Aminoethyl)thio]-1-(4-fluorophenyl)-2,5-pyrrolidinedione hydrochloride (CAS 1048649-31-5)
- 5-[4-(Prop-2-en-1-yl)-5-sulfanyl-4H-1,2,4-triazol-3-yl]-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridin-2-one (CAS 477852-98-5)
- 3-Ethyl-4-(phenylamino)-1H-1,2,4-triazol-5(4H)-one (CAS 75989-67-2)
- 2-Ethylhexylzinc bromide solution (CAS 312693-03-1)
- 5-Amino-3-cyclobutylpyrazole (CAS 326827-21-8)
- Allo-Thr5-Tirzepatide (CAS CATO-CPTD788934)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com