Capecitabine Impurity 36 CAS 1993-63-1
| CAS No. | 1993-63-1 |
| Molecular Formula | C5H6FN3O |
| Molecular Weight | 143.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Capecitabine Impurity 36 (CAS 1993-63-1, C5H6FN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Capecitabine Impurity 36 (C5H6FN3O) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H6FN3O |
| Molecular Weight | 143.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Capecitabine Standards
- Capecitabine Impurity 29 (CAS 5006-64-4)
- Capecitabine Impurity 49 (CAS 638-41-5)
- Capecitabine Impurity 50 (CAS 13039-75-3)
- Capecitabine Impurity 35 (CAS 1801-06-5)
- Capecitabine Impurity 33 (CAS 78341-97-6)
- Capecitabine Impurity 31 (CAS 72402-14-3)
- Capecitabine Impurity 46 (CAS 34980-66-0)
- Capecitabine Impurity 28 (CAS 862508-03-0)
Recommended Standards
- trans-3-Cyano-3-fluorocyclobutanecarboxylic acid (CAS 2471973-24-5)
- Linzagolix Impurity 3 (CAS 2168201-68-9)
- Methyl 4-fluoro-1H-pyrrole-2-carboxylate (CAS 475561-89-8)
- Prusogliptin Impurity 6 (CAS CATO-C4X-32846)
- Pantoprazole Impurity 52 (CAS 72830-08-1)
- Nefopam Impurity 3 (CAS 60725-36-2)
- Lenvatinib Impurity N3 (CAS 205810-04-4)
- 1-(4-Chloro-3-(trifluoromethyl)phenyl)ethanamine (CAS 1098069-36-3)
- Diflucortolone 21-Valerate (CAS 59198-70-8)
- Methyl 7-(but-3-en-2-yl)-6-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate (CAS 866393-52-4)
- 1-Cyclopropylpiperazin-2-one (CAS 907972-23-0)
- N-(1-(4-Methoxyphenyl)vinyl)acetamide (CAS 177750-10-6)
- (S)-2-(4-fluorophenyl)-2-(methylamino)ethan-1-ol (CAS 1213628-31-9)
- Liraglutide Impurity 16 TFA Salt (CAS CATO-C4X-199216)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com