Apalutamide Impurity 63 CAS 199330-60-4
| CAS No. | 199330-60-4 |
| Molecular Formula | C10H14N2O2 |
| Molecular Weight | 194.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Apalutamide Impurity 63.
As a process- or degradation-related impurity, Apalutamide Impurity 63 (CAS 199330-60-4, C10H14N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C10H14N2O2, Apalutamide Impurity 63 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 194.23 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H14N2O2 |
| Molecular Weight | 194.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2013 |
| Nitrogen Atoms | 2 |
Related Apalutamide Standards
- Apalutamide Impurity 37 (CAS CATO-C4X-274937)
- Apalutamide Impurity 70 (CAS 1427081-81-9)
- Apalutamide Impurity 49 (CAS CATO-C4X-274949)
- Apalutamide Impurity 43 (CAS 1513700-34-9)
- Apalutamide Impurity 14 (CAS 573762-62-6)
- Apalutamide Impurity 47 (CAS 1805396-62-6)
- Apalutamide Impurity 48 (CAS 1805601-57-3)
- Apalutamide Impurity 81 (CAS CATO-C4X-274981)
Recommended Standards
- 4-Butoxybenzoic acid (CAS 1498-96-0)
- N-Nitroso Pseudoephedrine (N-Nitroso Ephedrine HCl EP Impurity B) (CAS 1850-88-0)
- Solriamfetol Impurity 7 (CAS 178429-63-5)
- 1-Hydroxyphenanthrene (CAS 2433-56-9)
- Amikacin EP Impurity H (CAS 48237-20-3)
- Papaverine Impurity 13 Hcl (CAS 18813-60-0 (free base))
- Indacaterol Impurity 51 (CAS CATO-C4X-150051)
- (s)-Ethyl 2-amino-3,3-dimethylbutanoate hydrochloride (CAS 144054-74-0)
- N-(3-Acetyl-5-iodophenyl)acetamide (CAS 1393583-93-1)
- 5,5'-Difluoro-1,2-Bis(2-Aminophenoxy)Ethane-N,N,N',N'-Tetraacetic Acid (CAS 85233-21-2)
- 869296-13-9 EX-A2708 T-26c (CAS 869296-13-9)
- Dacomitinib Impurity 33 (CAS CATO-C4X-208633)
- N-(2-Chloro-4-fluorophenyl)-2-{[3-cyano-4-(trifluoromethyl)-5H,6H,7H,8H,9H-cyclohepta[b]pyridin-2-yl]sulfanyl}acetamide (CAS 626227-45-0)
- [a-Glu](Side chain transposition)- Semaglutide (CAS CATO-C4X-2226111)
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