Apalutamide Impurity 81 CAS CATO-C4X-274981
| CAS No. | CATO-C4X-274981 |
| Molecular Formula | C7H4F3N3 |
| Molecular Weight | 187.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Apalutamide Impurity 81 (CAS CATO-C4X-274981, C7H4F3N3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrile group, fluorine substitution, an aromatic ring system, Apalutamide Impurity 81 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 187.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4F3N3 |
| Molecular Weight | 187.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Apalutamide Standards
- Apalutamide Impurity 14 (CAS 573762-62-6)
- Apalutamide Impurity 47 (CAS 1805396-62-6)
- Apalutamide Impurity 48 (CAS 1805601-57-3)
- Apalutamide Impurity 43 (CAS 1513700-34-9)
- Apalutamide Impurity 49 (CAS CATO-C4X-274949)
- Apalutamide Impurity 21 (CAS CATO-C4X-274921)
- Apalutamide Impurity 37 (CAS CATO-C4X-274937)
- Apalutamide Impurity 63 (CAS 199330-60-4)
Recommended Standards
- 2,4-Dinitrophenol-d3 (CAS 93951-77-0)
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- Sorafenib Impurity 20 (CAS 329-01-1)
- Tiotropium Impurity 27 (CAS 3140-93-0)
- Hydrochlorothiazide Impurity (CAS 360-81-6)
- Betamethasone Impurity 21 (CAS 154713-07-2)
- 2-(4-Chloro-3-cyclopropyl-1H-pyrazol-1-yl)acetic acid (CAS 1006319-36-3)
- Avanafil Impurity 98 (CAS CATO-C4X-111898)
- 1-(3-Bromophenoxy)-2-nitro-4-(trifluoromethyl)benzene (CAS 1096951-88-0)
- (2-methoxy-4-nitro-phenyl)methanol (CAS 136507-14-7)
- 3-(4-Ethoxyphenyl)-1H-pyrazole-4-carbaldehyde (CAS 879996-58-4)
- Methyl (R)-4-(pyrrolidin-2-yl)benzoate hydrochloride (CAS 1381927-79-2)
- Tau Peptide (275-305) (Repeat 2 Domain) trifluoroacetate salt (CAS 330456-25-2)
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