Propranolol Impurity 24 CAS 20133-94-2
| CAS No. | 20133-94-2 |
| Molecular Formula | C13H13ClO2 |
| Molecular Weight | 236.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Propranolol Impurity 24.
As a process- or degradation-related impurity, Propranolol Impurity 24 (CAS 20133-94-2, C13H13ClO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H13ClO2, Propranolol Impurity 24 contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 236.69 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Propranolol Impurity 24 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13ClO2 |
| Molecular Weight | 236.69 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
Related Propranolol Standards
- Propranolol Chloro Impurity (CAS 112805-69-3)
- Propranolol Impurity 5 (CAS 132005-35-7)
- Propranolol Impurity 51 (CAS CATO-C4X-151951)
- Propranolol Impurity 57 (CAS CATO-C4X-151957)
- Propranolol Impurity 6 (CAS 20133-93-1)
- Propranolol impurity 44 (CAS CATO-C4X-151944)
- Propranolol impurity 45 (CAS CATO-C4X-151945)
- Propranolol impurity 46 (CAS CATO-C4X-151946)
Recommended Standards
- Rosuvastatin Impurity 140 (CAS 154026-92-3)
- Rosuvastatin Impurity 59 (CAS 404958-08-3)
- ethyl 5-chloro-1H,1aH,6H,6aH-cyclopropa[a]indene-1-carboxylate (CAS 2044796-16-7)
- ethyl 4-chloro-1H,1aH,6H,6aH-cyclopropa[a]indene-1-carboxylate (CAS 2044872-34-4)
- Cefdinir Impurity 46 (CAS CATO-C4X-121046)
- Megestrol Acetate EP Impurity J (CAS 14994-27-5)
- Pregabalin Impurity 132 (CAS CATO-C4X-1312132)
- 1-Allyl-3-((4-ethylphenyl)amino)pyrrolidine-2,5-dione (CAS 1008668-03-8)
- 2,3,6-Trimethyl-1H-indol-5-amine (CAS 165614-76-6)
- Benzyl 2-(trifluoromethyl)piperazine-1-carboxylate (CAS 2387600-86-2)
- Osimertinib Impurity 41 (CAS CATO-C4X-204541)
- (6-Chloro-5-methoxypyridin-3-yl)boronic acid (CAS 1548827-73-1)
- tert-Butyl 4-(4,6-dichloropyrimidin-2-yl)piperazine-1-carboxylate (CAS 1197341-88-0)
- Vialox Peptide(Pentapeptide-3) diacetate (CAS 725232-44-0)
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