Propranolol Impurity 6 CAS 20133-93-1
| CAS No. | 20133-93-1 |
| Molecular Formula | C13H13ClO2 |
| Molecular Weight | 236.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Propranolol Impurity 6 (CAS 20133-93-1, C13H13ClO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H13ClO2, Propranolol Impurity 6 contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 236.69 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Propranolol Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13ClO2 |
| Molecular Weight | 236.69 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
Related Propranolol Standards
- Propranolol Chloro Impurity (CAS 112805-69-3)
- Propranolol Impurity 5 (CAS 132005-35-7)
- Propranolol Impurity 24 (CAS 20133-94-2)
- Propranolol Impurity 51 (CAS CATO-C4X-151951)
- Propranolol Impurity 57 (CAS CATO-C4X-151957)
- Propranolol impurity 44 (CAS CATO-C4X-151944)
- Propranolol impurity 45 (CAS CATO-C4X-151945)
- Propranolol impurity 46 (CAS CATO-C4X-151946)
Recommended Standards
- 5-Chloro-7-((dimethylamino)methyl)quinolin-8-ol (CAS 100119-17-3)
- 2-(3-Chloro-4-methylphenyl)-6-methyl-4,5-dihydropyridazin-3(2H)-one (CAS 1049806-11-2)
- 2-Chloro-4-(piperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1070165-92-2)
- Rosuvastatin Impurity 140 (CAS 154026-92-3)
- Atrasentan Impurity 57 (CAS 1063836-16-7)
- Chloroquine Phosphate EP Impurity D (Chloroquine USP Related Compound G (Free Form)) (CAS 68121-48-2)
- Cefazolin Impurity 31 (CAS CATO-C4X-157731)
- (S)-2-(Isopropyl((1-methylpyrrolidin-2-yl)methyl)amino)acetic acid (CAS 1354000-86-4)
- N-(1H-Imidazol-2-yl)acrylamide (CAS 910564-53-3)
- 167875-39-0 Urs-12-ene-27,28-dioicacid, 3-[(6-deoxy-4-O-b-D-glucopyranosyl-b-D-galactopyranosyl)oxy]-, (3b)- (CAS 167875-39-0)
- 4-Ethynylbenzo-15-crown-5 (CAS 92710-94-6)
- 3-Chloro-4-Isopropoxybenzoic Acid (CAS 213598-07-3)
- tert-Butyl (R)-(4,4-difluoropiperidin-3-yl)carbamate (CAS 2089321-22-0)
- Tirzepatide Impurity 18 (CAS CATO-C4X-324018)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com