Dexamethasone EP Impurity J CAS 2036-77-3
| CAS No. | 2036-77-3 |
| Molecular Formula | C22H28O5 |
| Molecular Weight | 372.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Dexamethasone EP Impurity J (C22H28O5) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Dexamethasone EP Impurity J (CAS 2036-77-3, C22H28O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H28O5 |
| Molecular Weight | 372.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Dexamethasone Standards
- Dexamethasone EP Impurity D (CAS 24916-90-3)
- Dexamethasone impurity 70 (CAS CATO-C4X-116570)
- Dexamethasone EP Impurity I (CAS 14622-47-0)
- Dexamethasone impurity 91 (CAS CATO-C4X-116591)
- Dexamethasone Oxetanone (CAS 4089-36-5)
- Dexamethasone Impurity 104 (CAS 62800-49-1)
- Dexamethasone Impurity 120 (CAS CATO-C4X-1165120)
- Dexamethasone Impurity 23 (CAS 59860-99-0)
Recommended Standards
- Lubiprostone Impurity 44 (CAS CATO-C4X-113644)
- Lubiprostone Impurity 42 (CAS CATO-C4X-113642)
- Lubiprostone impurity 4 (CAS 2196182-47-3)
- Veraguensin (CAS 19950-55-1)
- LCZ-696 Impurity 42 (CAS CATO-C4X-169642)
- Nemonoxacin Impurity 96 (CAS CATO-C4X-312896)
- Ertapenem Impurity (CAS 770703-11-2)
- 7-TMCA Impurity 2 (CAS 126437-69-2)
- 2-(4-(Hydroxymethyl)-1,3-dioxolan-2-yl)ethanol (CAS 87133-51-5)
- H-Tyr-OMe · HCl (CAS 3417-91-2)
- 2-((7-Cyano-3,4-dihydro-2H-1,4-ethano-1,5-naphthyridin-6-yl)thio)-N-(4-fluorophenyl)acetamide (CAS 727679-31-4)
- 2-(2-Methoxyethoxy)pyrimidin-5-amine (CAS 1251024-07-3)
- C28 Triaromatic sterane, 20R (CAS 80382-33-8)
- Dulaglutide (CAS 923950-08-7)
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