Dexamethasone Impurity 104 CAS 62800-49-1
| CAS No. | 62800-49-1 |
| Molecular Formula | C22H27FO4 |
| Molecular Weight | 374.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Dexamethasone Impurity 104 (CAS 62800-49-1), a pharmacopoeial impurity reference standard (molecular formula C22H27FO4, MW 374.45 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Dexamethasone Impurity 104 (C22H27FO4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H27FO4 |
| Molecular Weight | 374.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | F-containing |
Related Dexamethasone Standards
- Dexamethasone Oxetanone (CAS 4089-36-5)
- Dexamethasone Impurity 120 (CAS CATO-C4X-1165120)
- Dexamethasone Impurity 23 (CAS 59860-99-0)
- Dexamethasone Impurity 39 (CAS 6762-51-2)
- Dexamethasone Impurity 95 (CAS CATO-C4X-116595)
- Dexamethasone Desfluoro 11-Epimer (CAS 78761-59-8)
- Dexamethasone EP Impurity J (CAS 2036-77-3)
- Dexamethasone EP Impurity D (CAS 24916-90-3)
Recommended Standards
- Donepezil EP impurity E (CAS CATO-C4X-103936)
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- N-(4-methoxyphenyl)-1-(phenylsulfonyl)piperidine-4-carboxamide (CAS 352672-88-9)
- Tenofovir Impurity 110 (CAS 20776-34-5)
- Fluticasone Impurity 110 (CAS CATO-C4X-1650110)
- Donepezil Impurity 51 (CAS CATO-C4X-103951)
- Tris(4-iodophenyl)amine (CAS 4181-20-8)
- 9,9,9',9',9'',9''-Hexa-p-tolyl-9H,9'H,9''H-2,2':7',2''-terfluorene (CAS 474918-42-8)
- 1-(6-Methoxypyridin-3-yl)butane-1,3-dione (CAS 1020039-43-3)
- 1-[4-(5-Methyl-furan-2-yl)-phenyl]-ethanone (CAS 886503-40-8)
- 1-Methyl-1,2,3,4-tetrahydroquinolin-6-ol (CAS 49742-76-9)
- 2-Oxo-1,2,3,4-tetrahydroquinoline-5-carboxylic acid (CAS 88371-29-3)
- His-Cyclic-Semaglutide (CAS CATO-C4X-2226182)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com