Phloroglucinol Impurity 7 CAS 203645-99-2
| CAS No. | 203645-99-2 |
| Molecular Formula | C12H9ClO2 |
| Molecular Weight | 220.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 220.65 g/mol gives Phloroglucinol Impurity 7 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Phloroglucinol Impurity 7 (CAS 203645-99-2) is a certified pharmaceutical impurity reference standard with the molecular formula C12H9ClO2 and a molecular weight of 220.65 g/mol.
The molecular framework of Phloroglucinol Impurity 7 (C12H9ClO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H9ClO2 |
| Molecular Weight | 220.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | Cl-containing |
Related Phloroglucinol Standards
- Phloroglucinol impurity 48 (CAS CATO-C4X-221748)
- Phloroglucinol impurity 49 (CAS CATO-C4X-221749)
- Phloroglucinol impurity 50 (CAS CATO-C4X-221750)
- Phloroglucinol Impurity 68 (CAS CATO-C4X-221768)
- Phloroglucinol Impurity 57 (CAS 738614-23-8)
- Phloroglucinol impurity 59 (CAS 1521-62-6)
- Phloroglucinol Diacetyl ; 100 MG (CAS 116345-96-1)
- Phloroglucinol impurity 44 (CAS 23957-21-3)
Recommended Standards
- Econazole impurity 29 (CAS 24155-32-6)
- Vismodegib Impurity 5 (CAS CATO-C4X-29905)
- Econazole impurity 27 (CAS 27087-94-1)
- 3-Chlorophenoxyphenol (CAS CATO-CCHM705319)
- Ibuprofen Impurity 41 (CAS 157369-85-2)
- Iguratimod Impurity 60 (CAS CATO-C4X-182660)
- Crisaborole Impurity 135 (CAS CATO-C4X-2021135)
- N-methyl-N-(prop-2-yn-1-yl)acetamide (CAS 18341-31-6)
- 1-(2-(1H-Pyrazol-1-yl)ethyl)-8-methyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepine (CAS 1422142-96-8)
- 3-(1-Aminocyclohexyl)tetrahydrothiophene 1,1-dioxide (CAS 1468601-79-7)
- Regorafenib Impurity 49 (CAS 90048-09-2)
- (2-Hydroxytrimethylene)bis(trimethylammonium) dichloride (CAS 55636-09-4)
- 4-tert-Butylbenzhydroxamic Acid (CAS 62034-73-5)
- Insulin Degludec Impurity 26 (CAS CATO-C4X-215726)
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