Dasatinib Impurity 36 CAS 2048106-50-7
| CAS No. | 2048106-50-7 |
| Molecular Formula | C22H26ClN7O2S |
| Molecular Weight | 488.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dasatinib Impurity 36.
Dasatinib Impurity 36 (CAS 2048106-50-7) is a certified pharmaceutical impurity reference standard with the molecular formula C22H26ClN7O2S and a molecular weight of 488.01 g/mol.
Structurally, Dasatinib Impurity 36 (C22H26ClN7O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 488.01 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dasatinib Impurity 36 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H26ClN7O2S |
| Molecular Weight | 488.01 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Dasatinib Standards
- Dasatinib (CAS 302962-49-8)
- Dasatinib Impurity 31 (CAS CATO-C4X-160731)
- Dasatinib Impurity 32 (CAS 2468737-83-7)
- Dasatinib Impurity 70 (CAS CATO-C4X-160770)
- Dasatinib Impurity 76 (CAS CATO-C4X-160776)
- Dasatinib Impurity 27 (CAS CATO-C4X-204527)
- Dasatinib Impurity 28 (CAS CATO-C4X-204528)
- Dasatinib D4 (CAS 1160297-08-4)
Recommended Standards
- Carbonylchlorohydrido[6-(di-t-butylphosphinomethyl)-2-(N,N-diethylaminomethyl)pyridine]ruthenium(II) (CAS 863971-62-4)
- 4-(4-(4-Chlorophenyl)-2-(2-phenylhydrazono)thiazol-3(2H)-yl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one (CAS 402945-96-4)
- Amidotrizoic Acid EP Impurity B (CAS 162193-52-4)
- N-(2-Chloro-4-fluorophenyl)-2-{[3-ethyl-7-(4-methylphenyl)-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl]sulfanyl}acetamide (CAS 1040632-56-1)
- Olaparib Impurity N2 (CAS 1956324-57-4)
- Nicorandil EP Impurity B (CAS 6265-73-2)
- Cloxacillin Impurity 39 (CAS CATO-C4X-159739)
- 2-(4-Chlorobenzyl)benzo[d]oxazol-5-amine (CAS 381200-35-7)
- 2-(1-(3-Methylpiperazin-1-yl)ethyl)thiazole hydrochloride (CAS 1289388-15-3)
- 5-Amino-4-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-1-phenyl-1,2-dihydro-3H-pyrrol-3-one (CAS 885460-77-5)
- 6-Fluoro-3-methylbenzo[b]thiophene-2-carbaldehyde (CAS 1398497-04-5)
- Dodecyl azide (CAS 13733-78-3)
- 4-Methyl-4a,5,6,7,8,9-hexahydrothieno[3',2':4,5]pyrimido[1,2-a]azepin-11(4H)-one (CAS 1710202-95-1)
- Semaglutide Impurity 161 (x TFA Salt) (CAS CATO-C4X-2226161)
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