Nicorandil EP Impurity B CAS 6265-73-2
| CAS No. | 6265-73-2 |
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Nicorandil EP Impurity B (CAS 6265-73-2), a pharmacopoeial impurity reference standard (molecular formula C8H10N2O2, MW 166.18 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C8H10N2O2, Nicorandil EP Impurity B contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 166.18 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 2 |
Related Nicorandil Standards
- Nicorandil Impurity N1 (CAS 46053-56-9)
- Nicorandil Impurity 17 (CAS 6265-74-3)
- Nicorandil Impurity 47 (CAS 13362-26-0)
- Nicorandil Impurity 57 (CAS 342018-76-2)
- Nicorandil Impurity 26 (CAS 14906-63-9)
- Nicorandil Impurity 43 (CAS 1570-45-2)
- Nicorandil Impurity 13 (CAS 896133-95-2)
- Nicorandil Impurity 28 (CAS CATO-C4X-190728)
Recommended Standards
- Thiamine /Vitamin B1 Impurity 18 (CAS 1886-34-6)
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- Nikethamide Impurity 3 (CAS 68254-63-7)
- Brivaracetam Impurity 166 (CAS 2755924-55-9)
- LCZ-696 Impurity 46 (CAS CATO-C4X-169646)
- Tadalafil Impurity 117 (CAS CATO-C4X-1087117)
- 6-Fluoro-imidazo[1,2-a]pyridine-3-carboxamidine hydrochloride (CAS 1313279-62-7)
- tert-butyl N-(N-methylcarbamimidoyl)carbamate (CAS 935530-93-1)
- 5-(Methylsulfonyl)quinolin-3-ol (CAS 1956384-81-8)
- 2-(Bicyclo[2.2.1]heptan-1-yl)ethan-1-amine hydrochloride (CAS 2287335-01-5)
- N-(1H-Benzo[d]imidazol-2-yl)-3-oxo-2,3-dihydro-1H-indene-1-carboxamide (CAS 1207053-89-1)
- Lapatinib Impurity 42 (CAS CATO-C4X-119142)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com