Dasatinib Impurity 28 CAS CATO-C4X-204528
| CAS No. | CATO-C4X-204528 |
| Molecular Formula | C22H26ClN7O2S |
| Molecular Weight | 488.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Dasatinib Impurity 28 (CAS CATO-C4X-204528) is a certified pharmaceutical impurity reference standard with the molecular formula C22H26ClN7O2S and a molecular weight of 488.01 g/mol.
Dasatinib Impurity 28 (C22H26ClN7O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Dasatinib Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H26ClN7O2S |
| Molecular Weight | 488.01 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Dasatinib Standards
- Dasatinib (CAS 302962-49-8)
- Dasatinib Impurity 31 (CAS CATO-C4X-160731)
- Dasatinib Impurity 32 (CAS 2468737-83-7)
- Dasatinib Impurity 36 (CAS 2048106-50-7)
- Dasatinib Impurity 70 (CAS CATO-C4X-160770)
- Dasatinib Impurity 76 (CAS CATO-C4X-160776)
- Dasatinib Impurity 27 (CAS CATO-C4X-204527)
- Dasatinib D4 (CAS 1160297-08-4)
Recommended Standards
- Amidotrizoic Acid EP Impurity B (CAS 162193-52-4)
- Amidotrizoic Acid Dihydrate - Impurity C (CAS 162193-53-5)
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- Rupatadine Impurity 35 (CAS 1632412-57-7)
- Ibandronate Sodium EP Impurity C (CAS 953805-81-7)
- L-Ornithine L-Aspartate Impurity 8 (CAS 14169-16-5)
- Etoposide Impurity 28 (CAS CATO-C4X-202428)
- 1-(6-Bromocinnolin-3-yl)ethanone (CAS 1509900-01-9)
- Atrasentan Impurity 80 (CAS 1058552-22-9)
- 2-(5-Bromo-2-chlorobenzyl)phenol (CAS CATO-C4X-1138189)
- (2E)-2,5,6,7,8,9-Hexahydro-2-(phenylmethylene)-3H-imidazo[1,2-a]azepin-3-one (CAS 1321895-49-1)
- n-(4-Amino-2-chlorophenyl)methanesulfonamide (CAS 18735-42-7)
- Methyl 2-(5-bromo-4-chloro-2-nitrophenyl)acetate (CAS 1820703-56-7)
- D-Thr5-Tirzepatide (CAS CATO-CPTD788926)
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