Lifitegrast Impurity 24 CAS 2049127-88-8
| CAS No. | 2049127-88-8 |
| Molecular Formula | C17H19NO4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Lifitegrast Impurity 24 (CAS 2049127-88-8, C17H19NO4SHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Lifitegrast Impurity 24 (C17H19NO4SHCl) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 369.86 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H19NO4S HCl |
| Molecular Weight | 369.86 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast (CAS 1025967-78-5)
- Lifitegrast Impurity 37 (CAS 1194550-56-5)
- Lifitegrast Impurity 49 (CAS 1194550-59-8)
- Lifitegrast Impurity 30 (CAS 1194550-61-2)
- Lifitegrast Impurity 23 (CAS 1194550-65-6)
- Lifitegrast Impurity 11 (CAS 1194550-67-8)
- Lifitegrast Impurity 39 (CAS 1194864-16-8)
- Lifitegrast Impurity N99 (CAS 1195655-47-0)
Recommended Standards
- Vinpocetine Impurity 36 (CAS CATO-C4X-184336)
- Formoterol impurity 131 (CAS 2386293-34-9（free base）)
- Bumetanide Impurity 21 (CAS CATO-C4X-198621)
- 4-Oxo-1,4-dihydropyrimido[1,2-b]indazole-2-carboxylic acid (CAS 92663-38-2)
- 2,5-Furandione, dihydro-3-(tetrapropenyl)-, polymer with aziridine (CAS 64162-11-4)
- Captopril Impurity J Hydrate Salt (CAS 801293-45-8)
- 2-(2-(2-Chloro-5,8-dimethoxyquinolin-3-yl)ethyl)isoindoline-1,3-dione (CAS 1105193-56-3)
- 4'-Ethoxy-2',3'-difluoro-4-propyl-2,3,4,5-tetrahydro-1,1'-biphenyl (CAS 1003218-25-4)
- tert-Butyl ((4-methyl-6-(piperazin-1-yl)pyridin-3-yl)methyl)carbamate (CAS 1355182-02-3)
- Heptapeptide-6 (CAS CATO-CPTD788823)
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