Erlotinib impurity 140 CAS 2055840-41-8
| CAS No. | 2055840-41-8 |
| Molecular Formula | C20H22BrN3O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Erlotinib impurity 140 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Erlotinib impurity 140 (CAS 2055840-41-8), a pharmacopoeial impurity reference standard (molecular formula C20H22BrN3O4HCl, MW 484.77 g/mol) used for the identification and quantification of trace impurities in APIs.
Erlotinib impurity 140 (C20H22BrN3O4HCl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Erlotinib impurity 140 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H22BrN3O4 HCl |
| Molecular Weight | 484.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 3 |
Related Erlotinib Standards
- Erlotinib Impurity 97 (CAS 1012057-39-4)
- Erlotinib Impurity 93 (CAS 1058132-82-3)
- Erlotinib impurity 136 (CAS 1058651-74-3)
- Erlotinib D4 (CAS 1130852-41-3)
- Erlotinib Impurity 123 (CAS 1145671-36-8)
- Erlotinib Hydrochloride Impurity 3 (CAS 1145671-52-8)
- Erlotinib Impurity 51 (CAS 115665-66-2)
- Erlotinib-d6 HCl (CAS 1189953-78-3)
Recommended Standards
- Lenvatinib Impurity 108 (CAS CATO-C4X-1140108)
- Dotinurad Impurity 77 (CAS 35458-33-4)
- Lansoprazole impurity 71 (CAS 2138848-91-4)
- 6-(4-Methoxyphenyl)-1,4-dimethyl-9H-carbazole (CAS 900015-04-5)
- (Z)-[(4-Bromophenyl)[2-(4-chlorophenyl)cyclopropyl]methylidene]amino 3-nitrobenzoate (CAS 338415-76-2)
- N-[2-[5-(1,3-Benzodioxol-5-ylmethylene)-4-oxo-2-thioxo-3-thiazolidinyl]ethyl]-2-chloroacetamide (CAS 885524-38-9)
- 3,6-Diaminopyrazine-2,5-dicarbonitrile (CAS 133940-72-4)
- 4-(4-Ethylpiperazin-1-yl)-3-methylaniline (CAS 882147-67-3)
- (1,2-Dithiolane-4,4-diyl)dimethanol (CAS 1121-96-6)
- Tirzepatide Impurity 25 X TFA Salt (CAS CATO-C4X-324025)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com