Posaconazole Impurity 126 CAS 208187-15-9
| CAS No. | 208187-15-9 |
| Molecular Formula | C20H26F2O4 |
| Molecular Weight | 368.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Posaconazole Impurity 126 (CAS 208187-15-9), a pharmacopoeial impurity reference standard (molecular formula C20H26F2O4, MW 368.41 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Posaconazole Impurity 126 (C20H26F2O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H26F2O4 |
| Molecular Weight | 368.41 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2016 |
| Halogen Content | F-containing |
Related Posaconazole Standards
- Posaconazole impurity 218 (CAS CATO-C4X-1208218)
- Posaconazole Impurity 26 (CAS CATO-C4X-120826)
- Posaconazole Impurity 99 (CAS CATO-C4X-120899)
- Posaconazole Impurity 197 (CAS CATO-C4X-1208197)
- Posaconazole Impurity 131 (CAS CATO-C4X-1208131)
- Posaconazole Impurity 134 (CAS CATO-C4X-1208134)
- Posaconazole Impurity 105 (CAS CATO-C4X-1208105)
- Posaconazole impurity 230 (CAS CATO-C4X-1208230)
Recommended Standards
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- Biapenem impurity 1 (CAS CATO-C4X-22731)
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- Tazobactam Impurity 2 (CAS CATO-C4X-12052)
- Rivaroxaban Impurity 76 (CAS 2305917-61-5)
- 3,3'-Oxybis[phenol (CAS 7034-31-3)
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- 6-(Cyclopropylamino)-4-methylnicotinic acid (CAS 1355197-15-7)
- (5-(4-Chloro-3-fluorophenyl)pyridin-3-yl)methanol (CAS 1346691-95-9)
- 3-(Azepan-2-yl)-5-propyl-1,2,4-oxadiazole (CAS 1564723-09-6)
- 5-Pyridin-4-yl-1,3,4-oxadiazol-2-amine (CAS 704-56-3)
- D-Pro31-Tirzepatide (CAS CATO-CPTD788905)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com