Posaconazole impurity 218 CAS CATO-C4X-1208218
| CAS No. | CATO-C4X-1208218 |
| Molecular Formula | C21H19F2NO3 |
| Molecular Weight | 371.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 371.38 g/mol gives Posaconazole impurity 218 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Posaconazole impurity 218 (CAS CATO-C4X-1208218) is a certified pharmaceutical impurity reference standard with the molecular formula C21H19F2NO3 and a molecular weight of 371.38 g/mol.
Posaconazole impurity 218 (C21H19F2NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H19F2NO3 |
| Molecular Weight | 371.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Posaconazole Standards
- Posaconazole Impurity 126 (CAS 208187-15-9)
- Posaconazole Impurity 26 (CAS CATO-C4X-120826)
- Posaconazole Impurity 99 (CAS CATO-C4X-120899)
- Posaconazole Impurity 131 (CAS CATO-C4X-1208131)
- Posaconazole Impurity 197 (CAS CATO-C4X-1208197)
- Posaconazole Impurity 72 (CAS CATO-C4X-120872)
- Posaconazole Impurity 73 (CAS CATO-C4X-120873)
- Posaconazole Impurity 134 (CAS CATO-C4X-1208134)
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