Posaconazole Impurity 99 CAS CATO-C4X-120899
| CAS No. | CATO-C4X-120899 |
| Molecular Formula | C18H21F2N3O3 |
| Molecular Weight | 365.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Posaconazole Impurity 99.
As a process- or degradation-related impurity, Posaconazole Impurity 99 (CAS CATO-C4X-120899, C18H21F2N3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Posaconazole Impurity 99 (C18H21F2N3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H21F2N3O3 |
| Molecular Weight | 365.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Posaconazole Standards
- Posaconazole Impurity 26 (CAS CATO-C4X-120826)
- Posaconazole Impurity 126 (CAS 208187-15-9)
- Posaconazole Impurity 197 (CAS CATO-C4X-1208197)
- Posaconazole impurity 218 (CAS CATO-C4X-1208218)
- Posaconazole Impurity 134 (CAS CATO-C4X-1208134)
- Posaconazole Impurity 105 (CAS CATO-C4X-1208105)
- Posaconazole impurity 230 (CAS CATO-C4X-1208230)
- Posaconazole Impurity 131 (CAS CATO-C4X-1208131)
Recommended Standards
- 2-[3,5-bis(methoxycarbonyl)-4-methylthiophene-2-sulfonamido]propanoic acid (CAS 1008594-95-3)
- N-benzyl-2-((3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl)thio)acetamide (CAS 255909-10-5)
- Ethyl 4-amino-6-(4-methoxybenzamido)quinoline-3-carboxylate (CAS 1018160-93-4)
- N-(6-methyl-4-oxothiochroman-3-yl)-3-(trifluoromethyl)benzamide (CAS 692738-27-5)
- Abiraterone Impurity 13 (CAS 154229-20-6)
- Oclacitinib Impurity 16 (CAS 2124221-18-5)
- Temozolomide EP Impurity B (CAS 113942-30-6)
- 2-Methyl-4-nitrobenzo[d]thiazol-5-amine (CAS 40671-24-7)
- 2-(1-Amino-4-ethylcyclohexyl)acetic acid (CAS 1339869-71-4)
- 4-Phenyl-5-[3-(trifluoromethyl)benzenesulfonyl]-1,2,3-thiadiazole (CAS 338398-39-3)
- 3-(5-Bromo-2-fluorophenyl)-2,2-dimethylpropan-1-ol (CAS 1489177-90-3)
- Alprazolam-D5 (1.0 mg/mL in Methanol) (CAS 1286073-82-2)
- 2,2,2-Trifluoro-1-pyridin-3-yl-ethylamine (CAS 912761-24-1)
- Peptide Fmoc-Thi-Thi-OH (CAS CATO-CPTD788552)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com