Nicergoline EP Impurity D CAS 20826-04-4
| CAS No. | 20826-04-4 |
| Molecular Formula | C6H4BrNO2 |
| Molecular Weight | 202.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Nicergoline EP Impurity D (CAS 20826-04-4, C6H4BrNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system, Nicergoline EP Impurity D is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 202.01 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4BrNO2 |
| Molecular Weight | 202.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Nicergoline Standards
- Nicergoline Impurity 13 (CAS 30341-93-6)
- Nicergoline Impurity 12 (CAS 35121-60-9)
- Nicergoline Impurity 22 (CAS CATO-C4X-208522)
- Nicergoline Impurity 14 (CAS CATO-C4X-208514)
- Nicergoline Impurity 18 (CAS CATO-C4X-208518)
- Nicergoline EP Impurity C (CAS 35155-28-3)
- Nicergoline Impurity 11 (CAS CATO-C4X-208511)
- Nicergoline Impurity 9 (CAS 23495-65-0)
Recommended Standards
- Erlotinib impurity 130 (CAS 585-79-5)
- 1-Bromo-2-Nitrobenzene (CAS 577-19-5)
- 1-Bromo-4-nitrobenzene (CAS 586-78-7)
- (2-Cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)boronic acid (CAS 1014614-10-8)
- Perampanel Impurity 21 (CAS CATO-C4X-243021)
- Regorafenib Impurity 12 (CAS CATO-C4X-104712)
- Piperacillin impurity 93 (CAS CATO-C4X-173293)
- 6-Chloro-3,4-dihydro-1H-pyrano[3,4-c]pyridine-8-carbaldehyde (CAS 2828459-16-9)
- 1,2-Dibromo-3,6-dichlorobenzene (CAS 100191-22-8)
- 17,17-Dimethyl-18-norandrosta-1,4,13-trien-3-one (CAS 77702-25-1)
- (E)-({5-[(4-bromophenyl)sulfanyl]-1-methyl-3-phenyl-1H-pyrazol-4-yl}methylidene)[(4-methylphenyl)methoxy]amine (CAS 321998-41-8)
- 6-((1-Isobutylcyclobutyl)methoxy)nicotinic acid (CAS 1427015-18-6)
- Ethyl 2-(difluoromethoxy)benzoate (CAS 773134-77-3)
- Tirzepatide Impurity 24 X TFA Salt (CAS CATO-C4X-324024)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com