Doxorubicin Impurity 5 CAS 1159977-23-7
| CAS No. | 1159977-23-7 |
| Molecular Formula | C21H14O8 |
| Molecular Weight | 394.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Doxorubicin Impurity 5 (CAS 1159977-23-7) is a certified pharmaceutical impurity reference standard with the molecular formula C21H14O8 and a molecular weight of 394.33 g/mol.
Structurally, Doxorubicin Impurity 5 (C21H14O8) contains a flavonoid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 394.33 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H14O8 |
| Molecular Weight | 394.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
Related Doxorubicin Standards
- Doxorubicin Impurity 24 (CAS CATO-C4X-203324)
- Doxorubicin Impurity 36 (CAS CATO-C4X-203336)
- Doxorubicin Dimer Impurity 17 (CAS 59325-98-3)
- Doxorubicin Impurity 39 (Mixture of Diastereomers) (CAS 210837-87-9)
- Doxorubicin Impurity 14 (CAS CATO-C4X-203314)
- Doxorubicin Impurity 7 (CAS 105612-58-6)
- Doxorubicin Impurity 8 (CAS 20982-41-6)
- Doxorubicin Impurity 6 (CAS 32384-98-8)
Recommended Standards
- Dolutegravir Impurity 28 (CAS 1646862-09-0)
- Selumetinib Impurity 6 (CAS CATO-C4X-30536)
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- 2-(Acetoxymethyl)-5-(6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-3,4-diyl diacetate (CAS 1093649-77-4)
- Tinidazole Impurity 27 (CAS 5648-30-6)
- Trimipramine EP Impurity C (CAS 315-69-5)
- Erlotinib Impurity 103 (CAS 299912-61-1)
- tert-Butyl 2-((2-chloroacetamido)methyl)pyrrolidine-1-carboxylate (CAS 1312455-25-6)
- N-(pyridin-2-ylmethyl)pyridin-4-amine (CAS 1039840-86-2)
- 2,2-dimethylcyclopentan-1-ol (CAS 37617-33-7)
- 2,5-Dichloro-3,4-ethylenedioxythiophene (CAS 225518-49-0)
- (5-Chloropyridin-2-yl)methanamine hydrochloride (CAS 871826-13-0)
- tert-Butyl (6-chloro-4-formylpyridin-2-yl)carbamate (CAS 1060801-14-0)
- Osteoblast Activating Peptide (mouse, rat) (H-7262.0500) (CAS 1222950-80-2)
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